Targeting oncogenic TβRI signaling inhibits androgen-independent prostate cancer growth and metastasis
Journal: Nature
Author: Per Flodbring Larsson et al., Sweden
A newly developed antibody therapy blocks a key metastatic signaling pathway, offering a promising precision medicine strategy to slow advanced prostate cancer progression.
Early microglial response to amyloid plaques drives sleep loss in Alzheimer’s disease
Journal: Alzheimer’s & Dementia
Author: Nicholas J. Constantino et al., USA
Microglia—not amyloid plaques alone—may drive early sleep loss in Alzheimer’s disease, revealing a reversible therapeutic target and promising early biomarker.
Explosive cytotoxicity of ruptoblasts bridges hormone surveillance and immune defense
Journal: Cell
Author: Chew Chai et al., USA
Scientists discovered ruptoblasts, an ancient immune cell type that explosively destroys pathogens, revealing an unexpected link between hormone signaling and immunity.
Targeting TROP2 in drug-tolerant persister cells delays EGFR tyrosine kinase inhibitor resistance in non-small-cell lung cancer
Journal: Cell Reports
Author: Jun Liao, Wenxiu Yao, Yan Yu et al., China
Targeting TROP2 in drug-tolerant cancer cells may delay resistance to EGFR inhibitors, offering a promising strategy for longer-lasting lung cancer treatment.
