Human lung organoid modelling of tissue-resident antiviral T cell responses
Journal: Nature
Author: Rathkey, Choi, van Unen et al., USA
Adult human distal lung organoids that keep their own resident T, B, NK and myeloid cells mounted virus-specific tissue-resident memory T cell responses to SARS-CoV-2; peptide boosting blunted later infection.
Modelling mouse embryogenesis from chemically induced totipotent stem cells
Journal: Nature
Author: Wu, Hu, Yu et al., China
From a single chemically induced totipotent-like stem cell type, Tsinghua scientists built embryo models that developed ex utero from morula to E8.5-like organogenesis, with extended culture producing functional cardiac tissue.
A human-induced pluripotent stem cell-derived spheroid model to investigate myelin injury and repair
Journal: Nature Neuroscience
Author: Ramesan, Mason, Kumar et al., Australia
Human iPSC spheroids with myelinating oligodendrocytes and reactive microglia remyelinated axons within eight weeks after demyelination, giving a human screening platform for multiple sclerosis therapies.
Spatially resolved multiomics of human meningeal development reveal lineage and disease dynamics
Journal: Nature Cell Biology
Author: To, Pett, Dufva et al., UK
A paired single-nucleus and spatial atlas of human meninges from 6 to 21 post-conception weeks maps blood–brain barrier programmes, supports a yolk-sac origin for meningeal macrophages and reveals altered fibroblast signalling in trisomy 21.
