SHR-A1811, a novel HER2-targeting antibody-drug conjugate, in advanced solid tumors (HORIZON-X): a global phase 1 trial
Journal: Signal Transduction and Targeted Therapy
Author: Yao, H., Yan, M., Tong, Z. et al., China
The novel HER2-targeting antibody-drug conjugate SHR-A1811 has demonstrated remarkable long-term efficacy and a manageable safety profile in patients with heavily pre-treated advanced solid tumors, notably achieving a median progression-free survival of 25 months in HER2-positive breast cancer.
Printed MoS2 memristive nanosheet networks for spiking neurons with multi-order complexity
Journal: Nature Nanotechnology
Author: Hadke, S.S., Klingler, C.N., Brown, S.T. et al., USA
Engineers have achieved a major breakthrough in bio-electronics: printing artificial neurons that can communicate directly with the biological brain. The study details the development of flexible, low-cost devices that generate electrical signals so realistic they successfully triggered responses in mouse brain tissue.
Nanoplate based digital PCR assay for effective quantification of plasma HPV circulating tumor DNA
Journal: npj Precision Oncology
Author: Parida, P., Baburaj, G., Shettigar, A.A. et al., India
The use of a high-volume, nanoplate-based digital PCR system has demonstrated exceptional 98% sensitivity in quantifying plasma HPV circulating tumor DNA, providing a highly accurate and reproducible method for monitoring disease burden and predicting relapse in cervical cancer patients.
Reconstructing tumor tissues in 3D: From organoids to bioengineered niches
Journal: Cell Stem
Author: Verena J. Kast et al., Germany
This comprehensive review outlines how integrating organoids with advanced biofabrication and microfluidics creates 3D tumor models that mirror patient-specific complexity, serving as clinical “avatars” to predict therapy response and accelerate the development of personalized cancer treatments.
