Synthetic lethality between RB-loss and E2F3 inhibition in small cell cancers targeted by pyrimidine synthesis blockade
Journal: Proceedings of the National Academy of Sciences
Author: Evan R. Abt et al., USA
Researchers identified a synthetic lethal vulnerability in RB-deficient small cell cancers, showing that suppressing E2F3 through pyrimidine synthesis inhibition may offer a broadly applicable therapeutic strategy across multiple neuroendocrine tumor types.
Tau T205 phosphorylation modulates engram cell recruitment and remote memory in mice
Journal: Nature
Author: Renée Kosonen et al., Australia
Researchers discovered that tau phosphorylation at T205 is essential for recruiting memory-storing engram cells, enabling long-term memory formation while revealing how tau dysfunction contributes to memory loss in neurodegenerative disease.
Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis
Journal: Cell
Author: Soichiro Asami et al., USA
Using 3D spatial transcriptomics and computational pseudotiming, researchers reconstructed hair follicle development in four dimensions, revealing hidden developmental programs and early molecular defects underlying hair loss.
Intravenous human umbilical cord-derived mesenchymal stem cell transplantation for ischemic stroke (MERIT): A phase 1 trial
Journal: Cell Reports Medicine
Author: Lili Cui et al., China
n the phase 1 MERIT trial, intravenous transplantation of umbilical cord-derived mesenchymal stem cells was well tolerated in subacute ischemic stroke patients and showed encouraging signs of functional recovery without serious safety concerns.
