Adipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma
Journal: Nature Communications
Author: Chen Song et al., China
Fat cells help multiple myeloma survive metabolic stress by supplying β-hydroxybutyrate, revealing a metabolic vulnerability that could enable new combination therapies.
Enhancing lung cancer subtype classification using histopathology foundation models in weakly-supervised and unsupervised learning frameworks
Journal: Nature Scientific Reports
Author: Karan V. Padariya et al., India
Histopathology foundation models accurately classify lung cancer subtypes across diverse populations, highlighting their potential to make computational pathology more scalable and clinically robust.
Toward the simultaneous detection of multiple diseases with a highly cost-effective cell-free DNA methylome test
Journal: PNAS
Author: Weihua Zeng et al., USA
A cost-effective cfDNA methylome test enables simultaneous detection of multiple cancers and organ abnormalities, opening a path toward comprehensive, noninvasive health monitoring.
Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis
Journal: Cell Stem Cell
Author: Victoria Osorio-Vasquez et al., USA
Patient-derived organoids uncover widespread CFTR dysfunction in chronic pancreatitis and show that CFTR modulators can restore ductal function and suppress inflammation.
