Human haematopoietic stem cells remember inflammatory stress
Journal: Nature
Author: Zeng, A.G.X., Nagree, M.S., Jakobsen, N.A. et al., Canada
Using single-cell multiomics and xenograft models, researchers identified a distinct human hematopoietic stem cell subset that retains a molecular memory of past inflammation, which restricts blood cell production, transmits a pro-inflammatory program to progeny, and is linked to an increased risk of all-cause mortality.
Decoy antibodies block extracellular HSP70, prevent self-signaling, and inhibit melanoma cell survival
Journal: Cell Reports
Author: Ben-Shalom N, Parikh S, Abramovitz L et al., Israel
Researchers discovered that anti-HSP70 antibodies generated from melanosome immunization inhibit melanoma tumor growth by blocking protumorigenic extracellular vesicle signaling, revealing a therapeutic axis that correlates with complete treatment responses in metastatic melanoma patients.
Metabolic characterization of the tumor microenvironment orchestrates therapeutic strategies and clinical outcomes in pancreatic cancer
Journal: Nature Communications
Author: Tang, R., Li, Y., Zhou, C. et al., China
By integrating scRNA-seq algorithms, researchers mapped pancreatic cancer metabolic heterogeneity to establish a TME-metabolism subtyping system (TMS1-3), successfully linking distinct immune-metabolic profiles to specific targeted therapies and clinical outcomes.
Patient-derived organoids from metastatic colorectal cancer mirror tumor heterogeneity and predict patient survival and drug sensitivity
Journal: Cancer Cell
Author: Kryeziu K, Klokkerud S, Totland M et al., Norway
By analyzing a biobank of 213 metastatic colorectal cancer organoids, researchers demonstrated that organoid morphology and successful establishment can mirror tumor heterogeneity to accurately predict patient survival, aggressiveness, and drug sensitivity for precision oncology guidance.
