Neural representation of action symbols in primate frontal cortex
Journal: Nature
Author: Lucas Y. Tian et al., USA
Researchers have identified a neural population in the macaque ventral premotor cortex that encodes recombinable “action symbols,” providing a localized neural substrate for symbolic operations and goal-directed behavior.
Exploring the efficacy evaluation model for androgenic alopecia using hair organoids: Transcending conventional hair research
Journal: Journal of Dermatological Science
Author: Seoyeon Kyung et al. South Korea
Researchers successfully developed a hair-bearing organoid model from embryonic stem cells to simulate androgenic alopecia with DHT, proving its efficacy as a robust, alternative preclinical platform for testing anti-hair loss therapies like minoxidil and SOYACT.
Related Article: Stress-Induced Hair Greying Model Using Human Skin Organoids
Whole-genome doubling drives immune evasion by silencing antigen presentation
Journal: Cancer Cell
Author: Foidart P, Li Z, Cai X et al., USA
Utilizing mouse mammary tumor models, researchers demonstrated that whole-genome doubling drives immune evasion by decreasing KDM6 activity and increasing succinate levels, which epigenetically silences MHCI transcriptional regulators and reduces antigen presentation, ultimately rendering these tumors more sensitive to anti-PD-L1 therapies.
Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia
Journal: Cancer Cell
Author: Shi X, Arreola A, Zhou Z et al., USA
Researchers identified a tumor-immune-neural circuit where tumor-derived CSF1 induces macrophages to produce GDF15, which acts through the central nervous system to amplify cancer cachexia and anorexia, highlighting this triad as a promising therapeutic target.
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