A stress-adaptive lipid kinase axis defines metabolic vulnerabilities in neuroendocrine prostate cancer
Journal: Cancer Cell
Author: Yang Zheng et al, USA
A new metabolic weakness in neuroendocrine prostate cancer could be exploited by combining two targeted therapies to trigger tumor cell death and extend survival.
Tumor-distal mediastinal lymph nodes harbor tumor-related progenitor exhausted T cells in lung cancer after neoadjuvant chemoimmunotherapy
Journal: Cell Reports Medicine
Author: Bin Zhang et al, China
Previously overlooked lymph nodes may preserve critical anti-tumor immune cells, offering new insights for improving lung cancer surgery and immunotherapy outcomes.
Superenhancers shape the landscape and repair dynamics of transcription-associated DNA breaks in cancer
Journal: Science Advances
Author: Osama Hidmi et al., Israel
Scientists uncovered how superenhancers drive DNA damage and repair in cancer, revealing a hidden source of genomic instability and potential therapeutic vulnerabilities.
Intestinal stem cells count self-renewal divisions to switch multipotency
Journal:
Author: Dong Tong, Anqi Li et al., China
Intestinal stem cells use an epigenetic division-counting mechanism to precisely control cell fate, ensuring balanced tissue renewal and regeneration.
