Chronic stress unleashes an intratumor phage-fibroblast-B cell circuit to promote tumor growth
Journal: Cell Cell
Author: Hilal Bashir et al., USA
Researchers uncovered a stress-driven gut microbiota pathway where bacterial phages suppress anti-tumor immunity, revealing new therapeutic targets to restore immune responses and inhibit cancer growth.
Human enterotoxigenic Escherichia coli (ETEC) infections elicit antibodies that broadly neutralize mucinases of pathogenic Escherichia coli and Shigella
Journal: Proceedings of the National Academy of Sciences
Author: David P. Buckley et al., USA
Researchers identified broadly neutralizing antibodies that block mucin-degrading enzymes shared by ETEC, Shigella, and pathogenic E. coli, revealing promising vaccine targets against multiple diarrheal pathogens.
Replication-stress-induced chromatin loops protect fork stability
Journal: Nature
Author: Vincent Gaggioli et al., Netherlands
Researchers discovered that replication stress triggers protective chromatin loops, stabilizing stalled DNA replication forks and preserving genome integrity by preventing degradation and mutagenesis.
Light-controlled disruption of cancer cell dormancy via photoswitchable stress hormone receptor degraders
Journal: Proceedings of the National Academy of Sciences
Author: Karina M. Freitag et al., Switzerland
Researchers developed light-activated photoPROTACs that selectively degrade glucocorticoid receptors, disrupting cancer cell dormancy with precise spatial and temporal control while minimizing systemic toxicity.
