Human Cerebral Organoids Reveal Broader Impact of Angelman Syndrome Gene
Journal: Communications Biology
Author: R. Chris Estridge et. al, USA
Researchers used human cerebral organoids to discover that UBE3A loss affects both neuronal and non-neuronal cells, disrupting brain development beyond neurons and revealing new therapeutic targets.
Gene Editing Safety Concerns as CRISPR Triggers Cellular Senescence in Stem Cells
Journal: Cell Reports Medicine
Author: Anastasia Conti et. al, Italy
CRISPR-Cas9 gene editing unexpectedly induces senescence and inflammation in blood stem cells, reducing their therapeutic potential. Researchers identify treatments to mitigate these adverse effects.
Spatial Biology Breakthrough Maps How Enhancers Control Gene Expression
Journal: Nature Communications
Author: Danni Hong et. al, China
Scientists develop eSpatial technology revealing how different enhancer combinations regulate the same gene across tissue regions, providing new insights into development and cancer heterogeneity.
Miniaturised CRISPR System Shows Promise for Safer Gene Therapy Delivery
Journal: Nature Communications
Author: Shufeng Ma et. al, China
Engineers create hpCasMINI, a compact CRISPR system small enough for viral delivery with enhanced editing efficiency, offering new possibilities for treating genetic diseases in patients.
