Spatial proteomics has been named Nature’s method of the year 2024. Basically, spatial proteomics reveals protein organization in tissues using advanced imaging techniques and creating detailed spatial protein maps.

This paper introduces advanced tools for high-throughput single-cell proteomics, enabling the precise analysis of proteins at the single-cell level. By improving sensitivity and throughput, these methods provide unprecedented insights into cellular behavior, helping researchers decode complex biological systems. Impact & Use: These innovations promise breakthroughs in personalized medicine, early disease detection, and targeted therapies by uncovering protein-level variations. Imagine real-time monitoring of individual cell changes during treatment or enhanced drug response prediction for tailored healthcare solutions. This technology could also revolutionize areas like nutrition by enabling personalized dietary plans based on individual cellular responses.

Method of the Year 2024: spatial proteomics. Nat Methods 21, 2195–2196 (2024).

https://doi.org/10.1038/s41592-024-02565-3