Our newly developed drug differs from previously known therapeutics in that it directly penetrates various tumor tissues to exert its efficacy. Therefore, it was essential to analyze the drug’s penetration within the tumor microenvironment. To evaluate this, we conducted permeability testing in a co-culture system of tumor organoids and cancer-associated fibroblasts (CAF). This approach allowed us to determine the optimal drug concentration required for effective therapeutic action.
As a result, we were not only able to assess the drug’s efficacy but also to compare the differences in penetration between various drug candidates. These findings provided valuable insights for optimizing drug formulations and overcoming the limitations of existing therapies. Thus, Lambda Biologics’s organoid co-culture platform has proven to be an effective tool for evaluating and optimizing drug penetration in the tumor microenvironment, contributing to the advancement of drug development.