Cancer Organoid

Colorectal Cancer Organoid

hCRC organoids exhibit a three-dimensional structure and cellular composition similar to colorectal cancer tissue.
They express proteins such as CK7, CK20, b-catenin, and CDX2, mirroring the characteristics of colorectal cancer tissue.
These organoids are highly valuable for analyzing genetic mutations in colorectal cancer and evaluating the efficacy of different chemotherapy treatments.


Price	1784€+ Login to see price
Organism	Human
Product Type	Organoid
Tissue	Colon
Disease	Colorectal cancer

Applications

Oncology

Small Molecule

Antibody

Cancer Vaccine

mRNA

Immune Cell

TME-CAF

Immuno Oncology

Macrophage

Regulatory T Cell

Tumor-Infiltrating Lymphocyte

Cytotoxic T Cell

Description

Cellular and structural similarity

Our colorectal cancer organoids accurately replicate patient tumors by expressing key markers CDX2, β-catenin, and CK20, underscoring their fidelity for cancer research and personalized treatment development. This molecular mimicry enables a profound understanding of colorectal cancer’s pathology and offers a promising avenue for therapeutic innovations.

Colorectal cancer organoid

	H&E	CDX2	β-catenin	CK20
Cancer tissue
Cancer organoid
Cancer organoid

Immunofluorescent staining with a proliferation marker (Ki-67), an epithelial marker (ECAD) and mature intestinal markers (DEFA5, OLFM4, MUC13, and KRT20).

Genetic mutation

Unlock the essence of precision in cancer treatment with our colorectal cancer organoids, mirroring the genetic markers of colorectal cancer.
Experience the future of testing you drugs, serving as an invaluable tool in capturing the patient-specific characteristics, thereby providing a more accurate platform for studying tumor biology and testing.
Dive into a new era of oncology, where your individuality guides our innovation.

Top mutated genes

Oncoplot of the top 26 most frequently mutated genes in 22 cases.

Colorectal cancer mutation PPI Network

Exploring genetic links in colorectal cancer crganoids: We analyze genetic correlations using a database of mutant proteins and their interactions to uncover critical insights into colorectal cancer.

Microsatellite instable

Tissue


Normal
Cancer
	BAT25 MSI (+) LOH: Uninformative	BAT26 MSI (+) LOH: Uninformative	D2S123 MSI (-) LOH: (-)	D5S346 MSI (+) LOH: (-)	D17S250 MSI (+) LOH: (-)

Organoid


Normal
Cancer
	BAT25 MSI (+) LOH: Uninformative	BAT26 MSI (+) LOH: Uninformative	D2S123 MSI (-) LOH: (-)	D5S346 MSI (+) LOH: (+) L=0.312	D17S250 MSI (+) LOH: (-)

Drug response

Embrace personalized medicine with our cutting-edge platform: Test your drug’s effectiveness against conventional treatments under optimal conditions and discover tailored therapeutic responses. Transform the standard with us—where your medication’s potential is as unique as you are.


5-FU
	Ctr	0.04μM	0.48μM	7.8μM	125μM	500μM
Oxaliplatin
	Ctr	0.12μM	0.32μM	0.8μM	20μM	100μM
Irinotecan
	Ctr	0.12μM	0.32μM	0.8μM	20μM	100μM

Organoid viability test CellTiterGlo vs WST

Embrace personalized medicine with our cutting-edge platform: Test your drug’s effectiveness against conventional treatments under optimal conditions and discover tailored therapeutic responses. Transform the standard with us—where your medication’s potential is as unique as you are.

Colorectal Cancer Organoid

Colorectal Cancer Organoid