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CODEX_main
Spatial Biology

CODEX

CODEX_main

  • Spatial Information Accessibility
▶ Gain insights from detailed spatial information within a slide, allowing for in-depth analysis of cellular composition and the networks of expression factors between cells.
  • Extensive Protein Marker Analysis
▶ Utilize barcoded antibodies to analyze up to 100 protein markers on a single tissue slide, enhancing the depth of your research.
  • Single-Cell Segmentation and Analysis
▶ Achieve precise segmentation and quantitative analysis of expression markers at the single-cell level, providing a high resolution of cellular functionality.
Organism
Human
Product Type
Organoid, Tissue
Tissue
Refer to our panel for detailed insights
Disease

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CODEX

CODEX was developed to overcome the limitations of existing IHC.
Multiplex-IHC is an experimental method that can confirm the expression of more than 100 biomarkers on one tissue slide.
It is possible to check the expression of various biomarkers on a single tissue slide and conduct comprehensive research on cell composition,
cell function and state, and cell-cell interaction.
CODEX analysis is performed using DNA barcoding and uses antibodies conjugated to unique oligonucleotide sequences.
By using a target specific barcode called dye-labelled reporter, it is possible to stain more than 100 biomarkers by
repeating the labeling cycle by dyeing three colors of fluorescence in one cycle.

CODEX
  • Staining more than 100 biomarkers on tissue slides 1 chapter.
  • Mapping of Millions of Cells Through Diverse Panel Combinations.
  • Single cell resolution analysis.
  • Cell phenotyping using marker staining combinations.
  • Cellular Neighborhood Analysis Utilizing Spatial Information of Cells.

Process

Immune profiling panels type

Immune panel - 31 markers

Read out

31 markers (charged slide)

To identify the mechanism of a new target, acquire spatial information
by simultaneously staining 31 markers in PDOX tissue.

Simultaneous staining of 31 markers in tumor tissue
Identification of treatmentmechanism through spatial analysis of cell types

Identifying immunological mechanisms underlying the efficacy of anticancer immunotherapy and discovering biomarker candidates through theapplication of spatial biology

AF Solution

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