Foamy microglia link oxylipins to disease progression in multiple sclerosis
Journal: Nature Neuroscience
Author: van der Vliet, D. et al., Netherlands
In brain tissue from patients with severe multiple sclerosis, researchers found large numbers of “foamy” immune cells packed with fat droplets after absorbing damaged myelin. These overloaded cells appear to switch from helping repair the brain to fueling ongoing damage and inflammation.
Overcoming CXCR4-Mediated T-Cell Exclusion Potentiates Antitumor Cytotoxicity in Fibrolamellar Carcinoma
Journal: Gastroenterology
Author: Jason A. Carter et al., USA
Researchers showed that combined CXCR4 and PD-1 blockade overcomes immune resistance in fibrolamellar carcinoma, enhancing T-cell infiltration and antitumor activity in human tumor slice cultures.
Single-cell multi-omic atlas and morphogen screening informs midbrain and hindbrain organoid engineering
Journal: Nature Neuroscience
Author: Nadezhda Azbukina et al., Switzerland
Researchers created a single-cell multi-omic atlas that improves midbrain and hindbrain organoid engineering, enabling generation of diverse, region-specific neuronal cell types.
AI-driven discovery of GPNMB CAR T cells as a multi-cancer therapy
Journal: Cell
Author: Daniel J. Baker et al., USA
Researchers developed an AI-driven pipeline that identified GPNMB as a promising CAR-T target, demonstrating potent anti-tumor activity across multiple blood and solid cancers.
