Dissection of the T cell infiltrate in mouse pancreatic tumors reveals an extensive and diverse tumor-reactive T cell repertoire
Journal: Science Advances
Author: Hannes Kehm et al., Germany
Researchers have discovered a surprisingly diverse “hidden army” of tumor-fighting T cells within pancreatic cancer, uncovering specific genetic triggers that could finally unlock personalized immunotherapy for this difficult-to-treat disease.
Cadherin-engineered microspheres enable scalable biofabrication of multilineage liver organoids
Journal: iScience
Author: Zheng Qin (秦政) et al., China
By utilizing “smart” biodegradable microspheres that mimic natural cellular glue, scientists have successfully engineered complex, self-organizing liver organoids from a single stem cell source, paving the way for scalable drug testing and organ repair.
DJ-1 inhibition reshapes tumor microenvironment and potentiates immune checkpoint inhibitors
Journal: Science Advances
Author: Haiying Zhu et al., China
By silencing a single protein called DJ-1, researchers have found a way to “reprogram” the immune system’s macrophages, turning them from tumor-protectors into powerful allies that help standard immunotherapies destroy resistant cancers.
Female metabolic resilience and male-biased protein quality defects under hypoxic in human brain organoids
Journal: iScience
Author: Romane Gaston-Breton et al., France
Using lab-grown brain organoids, researchers have uncovered a striking “survival gap” between the sexes, revealing that female brain cells adapt more resiliently to oxygen deprivation while male cells suffer from critical protein defects during injury.
