Scientists from the Institute for Bioengineering of Catalonia (IBEC) and West China Hospital, Sichuan University (WCHSU) have reversed Alzheimer’s disease in mice using nanoparticles that repair the brain’s vascular system, offering a potential new path to treat neurodegenerative disorders.
Rather than delivering drugs, these bioactive “supramolecular” nanoparticles activated the brain’s own clearance process for amyloid-β (Aβ) proteins – the toxic buildup linked to Alzheimer’s. By restoring the blood-brain barrier (BBB), the treatment reestablished the brain’s natural balance and reversed memory loss. In Alzheimer’s mouse models, just one hour after injection, Aβ levels dropped by 50-60%, and long-term behavioral tests showed complete recovery of cognitive performance. “Once the vasculature is repaired, it resumes clearing Aβ and other harmful molecules, allowing the system to recover,” explained Prof. Giuseppe Battaglia, ICREA Research Professor at IBEC and leader of the Molecular Bionics Group.
Image: Scientists reverse Alzheimer’s in mice with groundbreaking nanotech.” ScienceDaily. ScienceDaily, 30 October 2025.
The nanoparticles were precision-engineered to interact with specific cell receptors, acting as active drugs rather than passive carriers. This molecular control allowed them to modulate vascular function and restore the BBB’s waste-clearing capacity. “Our study shows rapid Aβ clearance and restoration of healthy blood-brain barrier function, leading to a remarkable reversal of Alzheimer’s pathology,” said Dr. Lorena Ruiz Perez, researcher at IBEC and Serra Hunter Assistant Professor at the University of Barcelona.
By targeting the vascular roots of Alzheimer’s, this supramolecular nanotherapy opens a promising new frontier in neuroscience – one where the brain’s own self-repair mechanisms can be reawakened to fight disease.
Research article:
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