Gastric cancer is one of the leading causes of cancer-related mortality worldwide. It is a malignant solid tumor characterized by poor prognosis due to difficulties in early diagnosis and its rapid progression. Unlike many other solid tumors that primarily metastasize via lymphatic or hematogenous routes, gastric cancer most commonly spreads through the peritoneum. Peritoneal metastasis is associated with particularly poor outcomes and marked resistance to treatment, highlighting the urgent need for innovative therapeutic strategies.
Gastric cancer exhibits diverse pathological subtypes and a complex tumor microenvironment (TME), which significantly affects drug permeability, immune responsiveness, and resistance to chemotherapy. As such, conventional two-dimensional (2D) cell lines or xenograft models are often insufficient to capture these intricate features, limiting their ability to accurately predict therapeutic responses in real patients.
To address these clinical limitations, Lambda Biologics has developed a precision drug evaluation platform based on three-dimensional (3D) gastric cancer organoids derived from patient tumor tissues. This platform accurately reflects the unique tumor characteristics and microenvironments of individual patients. Notably, it incorporates a co-culture system in which tumor cells are cultured alongside various stromal and immune cells, effectively reconstructing the native TME.
This advanced system enables comprehensive assessments of drug penetration, resistance mechanisms, and immune response within a physiologically relevant model. Unlike traditional models, it provides a closer approximation of actual clinical conditions, allowing for more precise evaluation of drug efficacy and safety. Lambda Biologics’ gastric cancer organoid platform ultimately aims to accelerate the development of novel therapeutics and support the implementation of personalized treatment strategies for highly heterogeneous cancers such as gastric cancer.