Organoid Heterogeneity Improves Cancer Treatment Prediction
Journal: Scientific Reports
Author: Jeremy D. Kratz et al., USA
Patient-derived cancer organoids reveal tumor heterogeneity missed by bulk sequencing, enhancing treatment response prediction and identifying resistant subclones, crucial for developing effective personalized therapies.
Stem Cell Therapy Breakthrough for Kidney Disease
Journal: Science Translational Medicine
Author: Toshikazu Araoka et al., Japan
iPSC-derived nephron progenitor cells show remarkable potential in treating both acute kidney injury and chronic kidney disease in mice, with VEGF-A secretion driving therapeutic effects and c-MET serving as a key marker.
AI Enables Label-Free Imaging in 3D Organoids
Journal: Cell Report Physical Science
Author: Rutger N.U. Kok et al., The Netherlands
LabelFreeTracker uses machine learning to visualize nuclei and membranes in bright-field images of organoids, eliminating phototoxicity while enabling cell tracking, proliferation analysis, and lineage tracing without fluorescent labeling
Bioprinting Meets Synthetic Biology in Diabetes Treatment
Journal: Trends in Biotechnology
Author: Davide Ribezzi et al., The Netherlands
Convergence of bioprinting and synthetic biology offers new pathways to create functional pancreatic tissue constructs, potentially liberating diabetes patients from insulin dependency through engineered transplantable grafts.
