2D Cell

B16F10

Pigmentation Insight ▶ Utilize the B16F1 cell line to gain valuable insights into melanin production mechanisms, essential for developing effective skin brightening treatments.
Efficacy Testing ▶ Leverage B16F1 cells to test and validate the effectiveness of brightening agents, ensuring they effectively reduce pigmentation and enhance skin luminosity.
Safety and Toxicity Assessments ▶ Employ B16F1 cells to conduct thorough safety and toxicity evaluations of new skin care products, guaranteeing they are safe for consumer use while achieving desired brightening effects.


Organism
Product Type
Tissue
Disease

Applications

In vitro 3T3 NR (OECD TG 432)

Comparison of cytotoxicityinduced by chemicals under exposure to non-cytotoxic levels of light versus no exposure to light.

2D Cell

MNT-1

In-depth Melanoma Analysis ▶ Utilize MNT-1 for detailed studies on melanoma mechanisms and therapeutic development.
Targeted Drug Testing ▶ Leverage MNT-1 cells for precise evaluations of new treatments' efficacy and safety.
Molecular Discovery ▶ Explore genetic insights and potential targets with the MNT-1 melanoma cell line.


Organism
Product Type
Tissue
Disease

Applications

In vitro 3T3 NR (OECD TG 432)

Comparison of cytotoxicityinduced by chemicals under exposure to non-cytotoxic levels of light versus no exposure to light.

2D Cell

Melanocyte

Enhanced Pigmentation Studies ▶ Utilize our melanocyte services to explore pigmentation processes and disorders in-depth, providing crucial insights into skin health and cosmetic development.
Tailored Cosmetic Testing ▶ Assess the efficacy of skincare products on real human melanocytes, ensuring safety and effectiveness tailored to diverse skin types.
Advanced Disease Modeling ▶ Leverage our melanocytes to model skin conditions such as vitiligo and hyperpigmentation, accelerating the discovery of targeted treatments.


Organism
Product Type
Tissue
Disease

Applications

Anti-melanogenesis assay

Assess the samples' capability to inhibit melanin production or secretion by utilizing melanocytes, the cells that regulate skin pigmentation.

2D Cell

BALB 3T3

Consistency and Reliability ▶ BALB 3T3 cells offer high reproducibility and consistent outcomes in biological experiments, enhancing the reliability of research results.
Versatile Research Applications ▶ These cells are extensively used in a variety of biological and medical research areas, including cancer research, toxicity testing, and drug response analysis. Their versatility broadens the scope of research possibilities.
Genetic Stability ▶ BALB 3T3 cells maintain stable characteristics over long periods due to low genetic variability, making them ideal for long-term studies and repetitive experiments.


Organism
Product Type
Tissue
Disease

Applications

In vitro phototoxicity test (OECD TG432)_3T3

Phototoxicity assessment following OECD Test Guideline 432 using the 3T3 cell line to evaluate the potential for phototoxic effects induced by exposure to ultraviolet (UV) light.

2D Cell

Cancer Associate Fibroblast (CAF)

Enhanced Tumor Mimicry ▶ Integrate CAFs with organoids to recreate the tumor microenvironment accurately, providing a realistic platform for oncology research.
Improved Drug Response Insight ▶ By simulating the complex interactions within the tumor microenvironment, our CAF-enhanced organoids offer deeper insights into drug efficacy and resistance mechanisms.
Accelerated Cancer Research ▶ Leverage the dynamic interaction between CAFs and tumor cells in our organoids to speed up the discovery of novel therapeutic targets and improve treatment strategies.


Organism	Human
Product Type	2D Cell
Tissue	Cancer Tissue
Disease

Applications

Colorectal cancer

CAFs support cancer stem cell maintenance, drug resistance, and tumor invasion by modulating the extracellular matrix and inflammatory cytokines

Non-small cell lung cancer

CAFs facilitate invasion, metastasis, angiogenesis, and immune evasion through ECM remodeling and cytokine secretion.

Pancreatic cancer

CAFs promote tumor growth, fibrosis, and immune suppression, creating a dense and resistant tumor microenvironment.

Breast cancer

CAFs enhance tumor growth, invasion, and immune evasion by producing growth factors, remodeling the ECM, and interacting with other stromal cells

Cholangiocarcinoma

CAFs induce fibrosis and ECM hardening, promoting tumor invasion, metastasis, and immune evasion

Immune Cell

Cytotoxic T cell

Establishing a process for isolating cytotoxic T cells that can directly attack cancer cells, creating an MHC-TCR interaction environment, and utilizing MHC I/II blockers to achieve an immune microenvironment in vivo.
Since obtaining blood from cancer patients is limited, the process is refined by co-culturing peripheral blood mononuclear cells (PBMC) derived from healthy individuals with cancer organoids from cancer patients.
This allows for the generation of cytotoxic T cells.


Organism	Human
Product Type	Organoid + Cytotoxic T cell
Tissue	Adaptive
Disease

Applications

Colorectal cancer

Colorectal cancer organoids faithfully mimic patient tumors, aiding drug testing and personalized treatment strategies through biomarker identification and high-throughput screening in a realistic tumor microenvironment

Non-small cell lung cancer

Non-small cell lung cancer organoids mirror patient tumor diversity and genetics, providing a robust platform for detailed cancer research, including drug responses and personalized treatment exploration

Pancreatic cancer

Pancreatic cancer organoids replicate patient tumor complexity, informing drug responses, disease modeling, and biomarker discovery to advance personalized treatment strategies and research

Breast cancer

Patient-derived breast cancer organoids mimic tumor complexities, facilitating diverse drug testing and precision medicine research for personalized treatment strategies

Cholangiocarcinoma

Cholangiocarcinoma organoids aid in personalized treatment strategies by replicating patient tumor complexity and advancing research through biomarker identification and drug screening

Immune Cell

Tumor-Infiltrating Lymphocyte

Tumor-Infiltrating Lymphocytes (TILs) are predominantly found in the microenvironment of tumors, including various types of lymphocytes that have infiltrated in and around tumor tissues.
Among them, CD8+ cytotoxic T cells and CD4+ helper T cells are major components.
Our approach involves isolating and expanding TILs from a patient’s tumor tissue, then evaluating the efficacy of anticancer agents in a tumor microenvironment containing cancer organoids and TILs.


Organism	Human
Product Type	Organoid + TIL
Tissue	Adaptive
Disease

Applications

Colorectal cancer

Non-small cell lung cancer

Pancreatic cancer

Pancreatic cancer organoids replicate patient tumor complexity, informing drug responses, disease modeling, and biomarker discovery to advance personalized treatment strategies and research

Breast cancer

Patient-derived breast cancer organoids mimic tumor complexities, facilitating diverse drug testing and precision medicine research for personalized treatment strategies

Cholangiocarcinoma
Cholangiocarcinoma organoids aid in personalized treatment strategies by replicating patient tumor complexity and advancing research through biomarker identification and drug screening

Immune Cell

Regulatory T cell

Regulatory T cells (Treg)” play a crucial role in maintaining immune homeostasis and tolerance by suppressing immune responses.
These lymphocytes inhibit T cell proliferation and cytokine production, thus preventing autoimmune reactions.
Our method involves evaluating the efficacy of an anticancer agent by treating a mixture of tumor organoids, cytotoxic T cells (CD8+ T cells), and regulatory T cells (Tregs) with the anticancer drug or drug candidate.


Organism	Human
Product Type	Organoid + T cell + Regulatory T cell
Tissue	Adaptive
Disease

Applications

Colorectal cancer

Non-small cell lung cancer

Pancreatic cancer

Pancreatic cancer organoids replicate patient tumor complexity, informing drug responses, disease modeling, and biomarker discovery to advance personalized treatment strategies and research

Breast cancer

Patient-derived breast cancer organoids mimic tumor complexities, facilitating diverse drug testing and precision medicine research for personalized treatment strategies

Cholangiocarcinoma

Cholangiocarcinoma organoids aid in personalized treatment strategies by replicating patient tumor complexity and advancing research through biomarker identification and drug screening

Immune Cell

Macrophage

A co-culturing platform of macrophages and organoids demonstrates varying organoid cytotoxic effects depending on the ratio of M1 macrophages to M2 macrophages.
Optimal cell death effects are established by co-culturing different ratios of functionally diverse immune cells.
This enables the identification of optimal conditions for co-culturing various immune cells, facilitating the selection of an appropriate platform for drug testing.


Organism	Human
Product Type	Organoid + T cell + Macrophage
Tissue	Innate
Disease

Applications

Colorectal cancer

Non-small cell lung cancer

Pancreatic cancer

Pancreatic cancer organoids replicate patient tumor complexity, informing drug responses, disease modeling, and biomarker discovery to advance personalized treatment strategies and research

Breast cancer

Patient-derived breast cancer organoids mimic tumor complexities, facilitating diverse drug testing and precision medicine research for personalized treatment strategies

Cholangiocarcinoma

Cholangiocarcinoma organoids aid in personalized treatment strategies by replicating patient tumor complexity and advancing research through biomarker identification and drug screening

Normal Organoid

Liver Organoid

Liver organoids replicate the intricate cellular composition of the human liver, facilitating detailed studies on liver biology and function. ▶ Replicate human liver for detailed studies on biology and function.
They enable modeling of liver diseases such as hepatitis and liver fibrosis, aiding in the understanding of disease mechanisms and potential therapies. ▶ Model hepatitis, fibrosis, aid disease understanding, therapy development.
Liver organoids mimic human liver metabolism, making them valuable for studying drug metabolism, toxicity, and personalized medicine approaches. ▶ Mimic human liver metabolism, study drug toxicity, personalized medicine.


Organism
Product Type	Organoid
Tissue	PSC
Disease

Applications

Inflammatory liver diseases

Inflammatory Bowel Disease (IBD) refers to a chronic condition characterized by inflammation within the gastrointestinal tract, causing inflammation of the intestinal walls.

Fatty liver disease

Lambda's Intestinal Fibrosis Model addresses these challenges by leveraging high mimetic human intestinal organoids to create a model of inflammatory bowel diseases.

Infectious Disease

As a virus-infected model, the utilization of tonsil, adenoid, and lung organoids allows for the evaluation of antiviral drug efficacy and facilitates virus research.