Morphodynamics of human early brain organoid development
Journal: Nature
Author: Akanksha Jain et al., Switzerland
This study uses light-sheet microscopy to unveil how human brain organoids self-organise over weeks, tracks cellular behaviours, and reveals matrix-dependent mechanisms driving.
Temporal Proteomics Maps Neural Development Dynamics
Journal: iScience
Author: Zeynep Yentür et. al., Germany
Within the scope of this research, a comprehensive proteome analysis reveals distinct secretion patterns during organoid neurogenesis, identifying synaptic proteins as key regulators of developmental timing and cellular differentiation.
Imaging Platform Transforms Single-Cell Analysis Scale
Journal: Cell
Author: Emanuele Pitino et. al, Spain
Scientists achieve cost-effective transcriptomic analysis of 10.9 million cells through STAMP, a multimodal imaging platform, circumventing sequencing constraints whilst maintaining spatial architecture for integrated phenotypic characterisation.
Systematic Mutagenesis Reveals Synonymous Variant Functionality
Journal: Nature Biotechnology
Author: Xuran Niu et. al, China
With the help of a base-editing library of 297,900 guide RNAs, researchers identify functionally significant synonymous mutations affecting cellular fitness through mRNA splicing and translational mechanisms, informing clinical variant interpretation.
