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Latest Research Trends (18 Apr 2025)

Latest Research Trends (18 Apr 2025)

WNT Signaling Drives Human Urothelial Organoid Development

Journal: iScience

Author: Na Qu et al., USA

Researchers developed human urothelial organoids from pluripotent stem cells by manipulating WNT signaling, offering a powerful model for studying developmental pathways in human urothelium

Engineered Microglia Enable Brain-Wide Therapeutic Protein Delivery

Journal: Cell Stem Cell

Author: Jean Paul Chadarevian et al., USA

CRISPR-edited human iPSC-microglia deliver Aβ-degrading enzymes throughout the brain, reducing pathology in Alzheimer’s and showing promise for treating diverse CNS disorders.

Mapping Melanocyte Development Using Pluripotent Stem Cells

Journal: iScience

Author: Jie Yang et al., China

Single-cell sequencing reveals signaling pathways and markers in melanocyte development from pluripotent stem cells, providing insights for pigment-related disease therapies.

Bifidobacterium Vesicles Enhance Immunotherapy in Lung Cancer

Journal: Nature Communications

Author: Ranjan Preet et al., USA

Gut bacteria-derived vesicles travel to lung tumors, modulate the microenvironment, and synergize with anti-PD-1 therapy, revealing new mechanisms of gut-tumor communication.

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