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Latest Research Trends (11 Apr 2025)

Organoid Heterogeneity Improves Cancer Treatment Prediction

Journal: Scientific Reports

Author: Jeremy D. Kratz et al., USA

Patient-derived cancer organoids reveal tumor heterogeneity missed by bulk sequencing, enhancing treatment response prediction and identifying resistant subclones, crucial for developing effective personalized therapies.

Stem Cell Therapy Breakthrough for Kidney Disease

Journal: Science Translational Medicine

Author: Toshikazu Araoka et al., Japan

iPSC-derived nephron progenitor cells show remarkable potential in treating both acute kidney injury and chronic kidney disease in mice, with VEGF-A secretion driving therapeutic effects and c-MET serving as a key marker.

AI Enables Label-Free Imaging in 3D Organoids

Journal: Cell Report Physical Science

Author: Rutger N.U. Kok et al., The Netherlands

LabelFreeTracker uses machine learning to visualize nuclei and membranes in bright-field images of organoids, eliminating phototoxicity while enabling cell tracking, proliferation analysis, and lineage tracing without fluorescent labeling

Bioprinting Meets Synthetic Biology in Diabetes Treatment

Journal: Trends in Biotechnology

Author: Davide Ribezzi et al., The Netherlands

Convergence of bioprinting and synthetic biology offers new pathways to create functional pancreatic tissue constructs, potentially liberating diabetes patients from insulin dependency through engineered transplantable grafts.

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