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Latest Research Trends (28 Mar 2025)

Latest Research Trends (28 Mar 2025)

ACM Enhances Neural Maturation

Journal: Nature Communications

Author: Honghui Zheng et al., China

The results of this study indicates that astrocyte-conditioned medium (ACM) promotes neural maturation in brain organoids, resulting in thicker neuronal layers, increased deep-layer neurons, and enhanced electrical activity, possibly due to protective lipid droplet accumulation.

Human Skeletal Stem Cell Diversity Shapes Bone Health and Disease

Journal: Cell Stem Cell

Author: Thomas H. Ambrosi et al., USA

Researchers identified four distinct human skeletal stem cell (hSSC) subtypes with unique functions across different skeletal sites. Aging and disease conditions promote a pathological shift toward fibrogenic hSSCs, limiting bone regeneration. Targeting specific gene pathways can restore proper hSSC diversity.

Blocking Prox1 Protein Transfer Unlocks Retinal Regeneration

Journal: Nature Communications

Author: Eun Jung Lee et al., South Korea

This research discovered that Prox1 protein, transferred from neurons to Müller glia cells, inhibits retinal regeneration in mammals. By blocking this transfer using antibodies, they restored regenerative capacity in mouse models of retinitis pigmentosa, delaying vision loss.

Sensory Nerve Targeting System Revolutionizes Bone Healing

Journal: Science Advances

Author: Kaicheng Xu et al., China

Scientists created a dual-function phage system that selectively promotes sensory nerve growth and accelerates bone regeneration by capturing natural growth factors. The system enhances healing by regulating immune responses through the Sema3A/XIAP/PAX6 pathway, reducing inflammation and shifting macrophages to repair mode.

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