The human retina can be broadlydivided into the Neural Retina and Retinal Pigmented Epithelium.
We confirmed the expression of specific markers present in each layer of the retina in theretinal organoids.
Around 25 days of cultivation, the presence of Retinal Ganglion Cells and Bipolar Cell layers was observed, along with the expression of the specific marker Paired Box Protein-6 (Pax6).
Furthermore, by observing changes in cell arrangement within the organoid andexamining the marker for photosensitive cells (Recoverin),
we confirmed thesimilarity of the produced retinal organoid to human tissue.
