Oncology

Zebrafish Drug Test

Immuno Oncology

Regulatory T Cell

Tumor-Infiltrating Lymphocyte

Cytotoxic T Cell

Anti-Virus

Influenza Virus

Disease Modeling

GI Tract Disease Model

Gland Disease Model

Metabolic Disease Model

Brain & CNS Disease Model

Respiratory and ENT Disease

Cosmetics

Anti-Inflammation

Skin Irritation

Microbiome

Probiotic Adhesion Assay (2D)

Host-Microbiome Study (3D)

Toxicity

OECD

Skin Irritation

Phototoxicity Test

Spatial Biology

Protein Solution

Technology Service

iPSC Generation

Viral Vector Cloning

Next-Generation Sequencing (NGS)

Normal Organoid

Intestinal Organoid

Skin & Hair Folicle Organoid

Kidney Organoid

Cardiac Organoid

Salivary Gland Organoid

Lacrimal Gland Organoid

Tonsil Organoid

Adenoid Organoid

Retinal Organoid

Cerebral Organoid

Midbrain Organoid

Cancer Organoid

Colorectal Cancer

Non-Small Cell Lung Cancer

Pancreatic Cancer

Cholangiocarcinoma

Hepatocarcinoma Cancer

Endometrial Cancer

Immune Cell

Regulatory T Cell

Tumor-Infiltrating Lymphocyte

Cytotoxic T Cell

2D Cell

Cancer Associate Fibroblast (CAF)

Spatial Biology

Research Service

iPSC Generation

Viral Vector Cloning

Next-Generation Sequencing (NGS)

Others

Artificial Skin

The full name

email@vos.com

MNT-1_main

2D Cell

MNT-1

MNT-1_main

In-depth Melanoma Analysis ▶ Utilize MNT-1 for detailed studies on melanoma mechanisms and therapeutic development.
Targeted Drug Testing ▶ Leverage MNT-1 cells for precise evaluations of new treatments' efficacy and safety.
Molecular Discovery ▶ Explore genetic insights and potential targets with the MNT-1 melanoma cell line.


Organism
Product Type
Tissue
Disease

Applications

In vitro 3T3 NR (OECD TG 432)

Comparison of cytotoxicityinduced by chemicals under exposure to non-cytotoxic levels of light versus no exposure to light.

Skin brightening

The skin brightening efficacy test is a thorough evaluation process designed to measure the effectiveness of skincare products in enhancing skin radiance.
It involves baseline assessments, consistent product application, and data collection using advanced analysis tools.

Assay process

Step 1_1: After culturing the cell line, it undergoes a stabilization process.
Step 1_2: Identify the concentration range for sample toxicity and establish the test concentration.

Step 2_1: Stabilize the cells by culturing them in a 48-well plate for approximately 1 day.
Step 2_2: After verifying the condition of the stabilized cells, treat them with the melanin production-stimulating hormone (a-MSH), either alone or simultaneously with the sample.
Step 2_3: Assess the whitening efficacy by comparing the amount of melanin production in the group treated with a-MSH alone and the group treated simultaneously with the sample

Step 3_1: Confirmation through repeated experiments, spanning from the initial cell seeding to the formation of melanin.
Step 3_2: Arranging raw data and generating quantitative or morphology data.

Read Out

Cell viability (% Neutral red uptake of dark controls)

Microscopy data (cell morphology)
Extracellular melanin content (%) data
Intracellualr melanin content (%) data

Stimulation

General screening stimulus: a-MSH (B16 cell line)
In a light-induced melanin production model, the stimulus source can be replaceable with UVB
Efficacy screening is feasible without irritants when utilizing cell lines other than the B16 cell line (high reproducibility).

Cell line

Murine melanoma cell line : B16F10 , Melan-A
Human melanoma cell lin : MNT-1
Primary human melanocytes

Lambda Biologics

Lambda Biologics

Contact

+49 (0) 152 293 76591

info@lambdabiologics.com

Deutscher Platz 5c

04103 Leipzig

Germany

@ 2024 . All rights reserved

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Deutscher Pl. 5c

04103 Leipzig

Germany

@ 2024 . All rights reserved

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Term of Services

Cookie Settings