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Organism | |
Product Type | Organoid |
Tissue | PSC |
Disease |
Applications
Inflammatory liver diseases
Inflammatory Bowel Disease (IBD) refers to a chronic condition characterized by inflammation within the gastrointestinal tract, causing inflammation of the intestinal walls.
Fatty liver disease
Lambda's Intestinal Fibrosis Model addresses these challenges by leveraging high mimetic human intestinal organoids to create a model of inflammatory bowel diseases.
Infectious Disease
As a virus-infected model, the utilization of tonsil, adenoid, and lung organoids allows for the evaluation of antiviral drug efficacy and facilitates virus research.
Our hPSC-derived liver organoids resemble real liver organs, enabling more accurate and reliable experimental results.
Liver organoids can be observed in a mature form with hepatic layers, bile duct structures architecture similar to actual liver tissue. They are also composed of various cells such as hepatocytes, cholangiocytes, Kupffer cells, stellate cells.
Our liver organoids more accurately mimic the functional characteristics of the liver compared to experiments using traditional HepG2 hepatocyte cell lines, allowing for more precise and varied experiments.
To induce a fatty liver model, we treated the liver organoids with free fatty acids.
It was confirmed that markers such as HNF4A, Albumin, and CYP3A4, which are indicative of healthy hepatocyte function, decreased in the damaged model.
This model can be used to evaluate effective substances related to fatty liver disease treatment.
@ 2024 . All rights reserved
@ 2024 . All rights reserved
