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Normal Organoid

Kidney Organoid

2830€+
Normal Organoid

Kidney Organoid

  • Highly Predictive Models
    Utilize our kidney organoids for precise toxicity assessments and efficacy evaluations, offering models that closely mimic human kidney responses.
  • Accelerated Testing Capabilities
    Speed up your drug development process with our organoids that allow for rapid and accurate testing of renal toxicity and therapeutic effectiveness.
  • Cost-Effective Research Tool
    Reduce research costs with our kidney organoids, which require fewer resources than traditional animal models while providing detailed insights into nephrotoxic effects and drug interactions.

Price
Organism
Human
Product Type
Organoid
Tissue
iPSC
Disease

Applications

Toxicity

Organoid Based

Disease Modeling

Metabolic Disease Model

Professor Lee Chang-seok Eulji University
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Tomocube (Spatial)
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HT-X1: A Label-Free Imaging Breakthrough for Organoid-Based Disease Modeling and Drug Screening

Traditional microscopy methods often require fluorescent labeling to analyze cellular structures, which can be time-consuming and invasive. In contrast, our HT-X1 system allows for high-resolution visualization of cellular morphology without...

Seoul National University College of Medicine
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Pioneering Spatial Protein Analysis in Korea: Advancing Clinical Pathology with Lambda Biologics’ Support

Traditional protein analysis has primarily focused on quantifying expression levels within tissue samples. However, recent advances in spatial analysis techniques have shifted attention toward evaluating not only expression levels, but...

K Research Institute
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ODISEI-Gut Platform Reveals Immune-Boosting Potential of Kimchi-Derived Bacterial Strain

Among the many fermented foods we consume, kimchi is particularly known for containing a diverse range of lactic acid bacteria, which are believed to influence the activation of immune cells...

Bundang Jesaeng General Hospital
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Multiplex Marker Analysis Enhances Research Efficiency with 31-Marker Detection on a Single Slide

We conducted a study focused on identifying disease-related markers using patient-derived tissue samples. However, traditional methods limited our ability to analyze multiple candidate markers simultaneously, and the limited availability of...

Description

Table of Contents

Differentiation of the vascularized and mature kidney organoids

The kidney organoids generated by protocols A and B had tubular structures, and their size was greater than the kidney organoids without kidney dECM.
The vascularization was extensively increased in the kidney organoids gen-erated by protocol A, and accelerated in those generated by protocol B.

PECAM1: Mature endothelial marker

Enhanced cascular network

Confirmation of increased PECAM1expression in Kidney Organoids grown with Protocol B.
Increased vascular network observed in the new differentiation protocol.

Increased maturity of tubular polarity and kidney gene expression

Enhanced polarization of the proximal tubules, with apical enrichment of the brush border marker lotus tetragonolobus lectin (LTL) and primary cilia, was observed in kidney organoids cultured by protocol A and B.

Decreased off-target cell

Identifying 18 cell types in kidney organoids through scRNAseq, the research demonstrated improved nephron cell differentiation in the presence of kidney dECM, notably with protocols A and B.
These protocols showed reductions in off-target cells, proliferating cells, and precursor cells.
Pseudo-time ordering further revealed enhanced cell maturity in organoids cultured with protocols A and B.

Unlock Superior Kidney Development with Advanced Podocyte Induction Protocols

Examining upregulated genes in podocytes generated by protocols A and B, the functional enrichment analysis for Gene Ontology (GO) biological processes revealed their predominant involvement in kidney and nephron development.
These findings suggest that kidney dECM influences genes associated with kidney development, enhancing maturation into nephron cells.
Notably, podocytes induced by protocols A and B exhibited a high resemblance to human and fetal podocytes and proximal tubule (PSB), while those induced by the Matrigel-based protocol showed lower similarity.
Furthermore, various cell types induced by protocols A and B demonstrated increased similarity to human and fetal kidney cell types.
Similar with human kidney
Similarity with human fetal kidney

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