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▶ Utilize our kidney organoids for precise toxicity assessments and efficacy evaluations, offering models that closely mimic human kidney responses.
▶ Speed up your drug development process with our organoids that allow for rapid and accurate testing of renal toxicity and therapeutic effectiveness.
▶ Reduce research costs with our kidney organoids, which require fewer resources than traditional animal models while providing detailed insights into nephrotoxic effects and drug interactions.
Organism | |
Product Type | Organoid |
Tissue | iPSC |
Disease |
Applications
Efficacy assay
Identify drugs capable of treating genetically damaged kidneys.
Toxicity test
Organoids are three-dimensional mini organs that mimic the functions of respective organs, reproducing their complex physiological structures and functions. Assess their toxicity with our advanced technology!
The kidney organoids generated by protocols A and B had tubular structures, and their size was greater than the kidney organoids without kidney dECM.
The vascularization was extensively increased in the kidney organoids gen-erated by protocol A, and accelerated in those generated by protocol B.
Confirmation of increased PECAM1expression in Kidney Organoids grown with Protocol B. Increased vascular network observed in the new differentiation protocol.
Enhanced polarization of the proximal tubules, with apical enrichment of the brush border marker lotus tetragonolobus lectin (LTL) and primary cilia, was observed in kidney organoids cultured by protocol A and B.
Identifying 18 cell types in kidney organoids through scRNAseq, the research demonstrated improved nephron cell differentiation in the presence of kidney dECM, notably with protocols A and B.
These protocols showed reductions in off-target cells, proliferating cells, and precursor cells.
Pseudo-time ordering further revealed enhanced cell maturity in organoids cultured with protocols A and B.
Examining upregulated genes in podocytes generated by protocols A and B, the functional enrichment analysis for Gene Ontology (GO) biological processes revealed their predominant involvement in kidney and nephron development. These findings suggest that kidney dECM influences genes associated with kidney development, enhancing maturation into nephron cells. Notably, podocytes induced by protocols A and B exhibited a high resemblance to human and fetal podocytes and proximal tubule (PSB), while those induced by the Matrigel-based protocol showed lower similarity. Furthermore, various cell types induced by protocols A and B demonstrated increased similarity to human and fetal kidney cell types.
@ 2024 . All rights reserved
@ 2024 . All rights reserved
