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kidney-organoid-thumb
Normal Organoid

Kidney Organoid

2830€+
Normal Organoid

Kidney Organoid

  • Highly Predictive Models
    Utilize our kidney organoids for precise toxicity assessments and efficacy evaluations, offering models that closely mimic human kidney responses.
  • Accelerated Testing Capabilities
    Speed up your drug development process with our organoids that allow for rapid and accurate testing of renal toxicity and therapeutic effectiveness.
  • Cost-Effective Research Tool
    Reduce research costs with our kidney organoids, which require fewer resources than traditional animal models while providing detailed insights into nephrotoxic effects and drug interactions.
Price
2830€+
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Organism
Human
Product Type
Organoid
Tissue
iPSC
Disease
–

Applications

Toxicity

Organoid Based

Disease Modeling

Metabolic Disease Model

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Description

Table of Contents
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Differentiation of the vascularized and mature kidney organoids

The kidney organoids generated by protocols A and B had tubular structures, and their size was greater than the kidney organoids without kidney dECM.
The vascularization was extensively increased in the kidney organoids gen-erated by protocol A, and accelerated in those generated by protocol B.

PECAM1: Mature endothelial marker

Enhanced cascular network

Confirmation of increased PECAM1expression in Kidney Organoids grown with Protocol B.
Increased vascular network observed in the new differentiation protocol.

Increased maturity of tubular polarity and kidney gene expression

Enhanced polarization of the proximal tubules, with apical enrichment of the brush border marker lotus tetragonolobus lectin (LTL) and primary cilia, was observed in kidney organoids cultured by protocol A and B.

Decreased off-target cell

Identifying 18 cell types in kidney organoids through scRNAseq, the research demonstrated improved nephron cell differentiation in the presence of kidney dECM, notably with protocols A and B.
These protocols showed reductions in off-target cells, proliferating cells, and precursor cells.
Pseudo-time ordering further revealed enhanced cell maturity in organoids cultured with protocols A and B.

Unlock Superior Kidney Development with Advanced Podocyte Induction Protocols

Examining upregulated genes in podocytes generated by protocols A and B, the functional enrichment analysis for Gene Ontology (GO) biological processes revealed their predominant involvement in kidney and nephron development.
These findings suggest that kidney dECM influences genes associated with kidney development, enhancing maturation into nephron cells.
Notably, podocytes induced by protocols A and B exhibited a high resemblance to human and fetal podocytes and proximal tubule (PSB), while those induced by the Matrigel-based protocol showed lower similarity.
Furthermore, various cell types induced by protocols A and B demonstrated increased similarity to human and fetal kidney cell types.
Similar with human kidney
Similarity with human fetal kidney

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