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Research Service

CRISPR-Cas9

10000€+
Research Service

CRISPR-Cas9

  • Achieve precise and reliable gene editing with our CRISPR-Cas9 technology.
    Enjoy consistent high editing efficiency and stability for your research.
    Consistent High Editing Efficiency and Stability
  • Offering expert solutions in cell reprogramming and gene editing, tailored to your needs.
    Specialized in Cell Reprogramming
  • IStreamline your workflow and accelerate discoveries by letting us handle the technical challenges.
    Concentrate on innovation while we support your research.

Price
Organism
Human
Product Type
Gene Editing
Tissue
Disease

Applications

Technology Service

CRISPR-Cas9

Professor Lee Chang-seok Eulji University
Customer insight

Advancing K-Beauty with Skin Organoids: A Next-Generation Platform for Non-Animal Testing and High-Precision Cosmetic Innovation

With the global rise of K-beauty, the cosmetics industry continues to grow steadily. Since the ban on animal testing for cosmetics in Korea in 2017, various alternative testing methods have...

Tomocube (Spatial)
Customer insight

HT-X1: A Label-Free Imaging Breakthrough for Organoid-Based Disease Modeling and Drug Screening

Traditional microscopy methods often require fluorescent labeling to analyze cellular structures, which can be time-consuming and invasive. In contrast, our HT-X1 system allows for high-resolution visualization of cellular morphology without...

Seoul National University College of Medicine
Customer insight

Pioneering Spatial Protein Analysis in Korea: Advancing Clinical Pathology with Lambda Biologics’ Support

Traditional protein analysis has primarily focused on quantifying expression levels within tissue samples. However, recent advances in spatial analysis techniques have shifted attention toward evaluating not only expression levels, but...

K Research Institute
Customer insight

ODISEI-Gut Platform Reveals Immune-Boosting Potential of Kimchi-Derived Bacterial Strain

Among the many fermented foods we consume, kimchi is particularly known for containing a diverse range of lactic acid bacteria, which are believed to influence the activation of immune cells...

Bundang Jesaeng General Hospital
Customer insight

Multiplex Marker Analysis Enhances Research Efficiency with 31-Marker Detection on a Single Slide

We conducted a study focused on identifying disease-related markers using patient-derived tissue samples. However, traditional methods limited our ability to analyze multiple candidate markers simultaneously, and the limited availability of...

Description

Table of Contents

Fabry’s Disease Modeling

Fabry disease is a rare X-linked inherited disorder resulting from a deficiency or absence of the lysosomal enzyme α-galactosidase A (α-Gal A).
This deficiency disrupts the glycosphingolipid metabolic pathway, causing the accumulation of globotriaosylceramide (Gb3) and related glycosphingolipids within lysosomes.
This accumulation impairs cellular morphology and function, leading to a multisystemic condition associated with severe complications such as stroke, heart failure, cardiac arrhythmia, and end-stage renal disease.
Unfortunately, these complications contribute to a reduced life expectancy in individuals with Fabry disease.
Lambda has developed a model for Fabry’s disease, creating kidney organoids through CRISPR-Cas9 gene editing.
This model closely mirrors the pathological phenotype of human Fabry disease and responds to enzyme replacement therapy.
Consequently, it stands as a valuable tool in the development of treatments for Fabry disease.

Assay process

Structural changes

Gb3 (globotriaosylceramide) accumulation

Lipid accumulation (Oil red O)

Enzyme replacement therapy in Fabry kidney organoids

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