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Cancer Associate Fibroblast (CAF)_main
2D Cell

Cancer Associate Fibroblast (CAF)

2D Cell

Cancer Associate Fibroblast (CAF)

  • Enhanced Tumor Mimicry
▶ Integrate CAFs with organoids to recreate the tumor microenvironment accurately, providing a realistic platform for oncology research.
  • Improved Drug Response Insight
▶ By simulating the complex interactions within the tumor microenvironment, our CAF-enhanced organoids offer deeper insights into drug efficacy and resistance mechanisms.
  • Accelerated Cancer Research
▶ Leverage the dynamic interaction between CAFs and tumor cells in our organoids to speed up the discovery of novel therapeutic targets and improve treatment strategies.

Price
Organism
Product Type
2D Cell
Tissue
Cancer Tissue
Disease

Applications

Colorectal cancer

CAFs support cancer stem cell maintenance, drug resistance, and tumor invasion by modulating the extracellular matrix and inflammatory cytokines

Non-small cell lung cancer

CAFs facilitate invasion, metastasis, angiogenesis, and immune evasion through ECM remodeling and cytokine secretion.

Pancreatic cancer

CAFs promote tumor growth, fibrosis, and immune suppression, creating a dense and resistant tumor microenvironment.

Breast cancer

CAFs enhance tumor growth, invasion, and immune evasion by producing growth factors, remodeling the ECM, and interacting with other stromal cells

Cholangiocarcinoma

CAFs induce fibrosis and ECM hardening, promoting tumor invasion, metastasis, and immune evasion

Professor Lee Chang-seok Eulji University
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Table of Contents

Cancer associate fibroblast (CAF)

Cancer-Associated Fibroblasts(CAFs) play a crucial role in the evaluation of anticancer drugs.
They modulate the cancer environment, making it challenging for anticancer drugs to infiltrate and limiting treatment effectiveness.
Additionally, they regulate immune responses, restricting the efficacy of anticancer immunotherapy.
Moreover, CAFs promote cancer invasion and metastasis, potentially inducing resistance to anticancer drugs.
Considering these functions of CAFs is crucial for accurately assessing the efficacy of anticancer drugs and developing strategies to address these challenges.

Tumor Microenvironment Mimicked by CAF (CIPCO Model)v

Similar to actual pathological results in patients

Various CAF subtypes replicate the actual tumor microenvironment

CIPCO exhibits lower drug permeability compared to simple organoids

When co-administered with a drug that enhances drug permeability, Gemcitabine sensitivity is increased.
The CIPCO model recreates the physical environment surrounding cancer cells, reproducing drug permeability in patient cancer tissues.

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