Integrating Cancer-Associated Fibroblasts (CAF) with organoids enables precise reconstruction of the tumor microenvironment, enhancing the physiological relevance of in vitro cancer models. These CAF-integrated organoids capture the complex crosstalk between stromal and tumor cells, providing deeper insights into drug efficacy, resistance mechanisms, and tumor progression. By modeling these interactions more accurately, researchers can accelerate the discovery of therapeutic targets and refine strategies for personalized oncology.
Price | |
Organism | |
Product Type | Organoid + CAF |
Tissue | Cancer Tissue |
Disease |
Applications
Colorectal cancer
CAFs support cancer stem cell maintenance, drug resistance, and tumor invasion by modulating the extracellular matrix and inflammatory cytokines
Non-small cell lung cancer
CAFs facilitate invasion, metastasis, angiogenesis, and immune evasion through ECM remodeling and cytokine secretion.
Pancreatic cancer
CAFs promote tumor growth, fibrosis, and immune suppression, creating a dense and resistant tumor microenvironment.
Breast cancer
CAFs enhance tumor growth, invasion, and immune evasion by producing growth factors, remodeling the ECM, and interacting with other stromal cells
Cholangiocarcinoma
CAFs induce fibrosis and ECM hardening, promoting tumor invasion, metastasis, and immune evasion
Our newly developed drug differs from previously known therapeutics in that it directly penetrates various tumor tissues to exert its efficacy. Therefore, it was essential to analyze the drug’s penetration...
Cancer-Associated Fibroblasts (CAFs) play a crucial role in the evaluation of anticancer drugs. They modulate the cancer environment, making it challenging for anticancer drugs to infiltrate and limiting treatment effectiveness. Additionally, they regulate immune responses, restricting the efficacy of anticancer immunotherapy. Moreover, CAFs promote cancer invasion and metastasis, potentially inducing resistance to anticancer drugs. Considering these functions of CAFs is crucial for accurately assessing the efficacy of anticancer drugs and developing strategies to address these challenges.
When co-administered with a drug that enhances drug permeability, Gemcitabine sensitivity is increased.
The CIPCO model recreates the physical environment surrounding cancer cells, reproducing drug permeability in patient cancer tissues.
Cancer-Associated Fibroblasts (CAFs) are key stromal cells within the tumor microenvironment that actively influence cancer progression, metastasis, and therapeutic response. They secrete extracellular matrix components, cytokines, and growth factors that support tumor growth and immune modulation.
CAFs provide a physiologically relevant model for studying tumor–stroma interactions and drug resistance mechanisms. When co-cultured with tumor or immune cells, they help recreate the complexity of the in vivo tumor microenvironment, enabling more predictive preclinical testing and the development of anti-stromal or combination therapies.
Lambda Biologics’ CAFs are derived from patient tumor samples, preserving native phenotypes and molecular signatures. They can be integrated into organoid or immune co-culture systems, offering a reproducible and human-relevant platform for oncology research and therapeutic screening.
