OPAL - Lambda Biologics

Oncology

Zebrafish Drug Test

Immuno Oncology

Regulatory T Cell

Tumor-Infiltrating Lymphocyte

Cytotoxic T Cell

Anti-Virus

Influenza Virus

Disease Modeling

GI Tract Disease Model

Gland Disease Model

Metabolic Disease Model

Brain & CNS Disease Model

Respiratory and ENT Disease

Cosmetics

Anti-Inflammation

Skin Irritation

Microbiome

Probiotic Adhesion Assay (2D)

Host-Microbiome Study (3D)

Toxicity

OECD

Skin Irritation

Phototoxicity Test

Spatial Biology

Protein Solution

Technology Service

iPSC Generation

Viral Vector Cloning

Next-Generation Sequencing (NGS)

Normal Organoid

Intestinal Organoid

Skin & Hair Folicle Organoid

Kidney Organoid

Cardiac Organoid

Salivary Gland Organoid

Lacrimal Gland Organoid

Tonsil Organoid

Adenoid Organoid

Retinal Organoid

Cerebral Organoid

Midbrain Organoid

Cancer Organoid

Colorectal Cancer

Non-Small Cell Lung Cancer

Pancreatic Cancer

Cholangiocarcinoma

Hepatocarcinoma Cancer

Endometrial Cancer

Immune Cell

Regulatory T Cell

Tumor-Infiltrating Lymphocyte

Cytotoxic T Cell

2D Cell

Cancer Associate Fibroblast (CAF)

Spatial Biology

Research Service

iPSC Generation

Viral Vector Cloning

Next-Generation Sequencing (NGS)

Others

Artificial Skin

The full name

email@vos.com

OPAL

Adaptive Spatial Profiling Solution

Starting cost

€ 0 +

€15.380+

€4.480+

€8.200+

Preparing

GeoMX

€10.890+

Preparing

Hyperion

€3.200+

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OPAL

OPAL has the advantage of being able to stain freely without restrictions on the host of the primary antibody, making it easy to use antibodies already available in the laboratory and increasing experimental flexibility.

It is possible to stain up to 8 biomarkers at a time, and has the advantage of being relatively cheaper than CODEX staining.

OPAL

6 marker staining capabilities on a single tissue slide.
High compatibility with existing IHC and freedom to choose biomarkers.
Construction of organoid-optimized panels for tissue-level analysis.
Solutions optimized for diagnostic marker testing.
Rapid cellular phenotyping and neighborhood analysis.

Process

Staining

2 days

FFPE or FF tissue section
Antigen Unmaking
Tissue staining
Primary antibody incubation
Reporter plate preparation
PCF run

Image

1-3 days per slide

Continuous speed improvements
Workflow simplification
Consistent imaging methods

Analyze

4 months

Proprietary data compression
Solutions serve every user need
Consistent image analysis methods

Step. 1 : Sample preparation
Step. 2 : Tissue staining (primary antibody & fluorophore)
Step. 3 : PIF run
Step. 4 : Data analysis

Readout

Liver organoid

H&E

OPAL

Merge

DAPI

ALB

ALB

PDGFR

BSEP

COL1

CD31

Brain organoid

H&E

OPAL

Merge

DAPI

NeuN

NF-M

MAP2

GFAP

SOX2

NG2

Colon organoid

H&E

OPAL

Merge

DAPI

ChaA

ECAD

SOX9

Lyz

Muc2

SI

Confirmation of similarity using OPAL staining in organoids derived from various organs undergoing differentiation.

OPAL

Merge

DAPI

OLFM4

SLC26A3

MUC2

FCGBP

KRT20

TMM40

Outcomes of organoid and co-culture cell analysis through OPAL staining

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Lambda Biologics

Lambda Biologics

Contact

+49 (0) 152 293 76591

info@lambdabiologics.com

Deutscher Platz 5c

04103 Leipzig

Germany

@ 2024 . All rights reserved

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Deutscher Pl. 5c

04103 Leipzig

Germany

@ 2024 . All rights reserved

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Term of Services

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