Tonsil organoids encompass various cell types, including epithelial and immune cells, and mimic the lymphoid structures found in tonsils.
Tonsil organoids serve as versatile platforms for studying immune responses, infections, and diseases affecting tonsils. They are valuable for drug testing and can be genetically manipulated to explore specific genes and pathways related to tonsil development and diseases.
Tonsil organoids provide a scalable and reproducible method for in vitro research, contributing to our understanding of tonsil biology and potential clinical applications.
Tonsil organoid
As a virus-infected model, the
utilization of tonsil, adenoid, and lung organoids allows for the evaluation of antiviral drug efficacy and facilitates virus research.
Cell Type
· ASC
Assay
· SARS-COV-2 infection model
Verification of similarities between tonsil and organoid characteristics through H&E staining, Alcian blue, PAS staining, and Masson’s trichrome.
Validation of tonsil epithelial markers, such as NGFR, ITGA6, CD44, MUC1, E-cadherin, an Ki67, in organoids through IF/IHC, demonstrating their presence, similar to the tissue.
