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Lambda boasts consistent high editing efficiency and stability in CRISPR-Cas9 technology.
We specialize in cell reprogramming and gene editing, enabling you to concentrate on your research as we optimize the process, alleviating the burden on your shoulders.
CRISPR-Cas9
Lambda has developed a model for Fabry’s disease, creating kidney organoids through CRISPR-Cas9 gene editing. This model closely mirrors the pathological phenotype of human Fabry disease and responds to enzyme replacement therapy. Consequently, it stands as a valuable tool in the development of treatments for Fabry disease.
Cell Type
· ASC
Organoid type
· Kidney organoid
Fabry disease is a rare X-linked inherited disorder resulting from a deficiency or absence of the lysosomal enzyme α-galactosidase A (α-Gal A).
This deficiency disrupts the glycosphingolipid metabolic pathway, causing the accumulation of globotriaosylceramide (Gb3) and related glycosphingolipids within lysosomes.
This accumulation impairs cellular morphology and function, leading to a multisystemic condition associated with severe complications such as stroke, heart failure, cardiac arrhythmia, and end-stage renal disease. Unfortunately, these complications contribute to a reduced life expectancy in individuals with Fabry disease.
Lambda has developed a model for Fabry’s disease, creating kidney organoids through CRISPR-Cas9 gene editing. This model closely mirrors the pathological phenotype of human Fabry disease and responds to enzyme replacement therapy. Consequently, it stands as a valuable tool in the development of treatments for Fabry disease.
Leaky gut syndrome is an intestinal disease in which bacteria and toxins enter the bloodstream due to a weakened intestinal barrier.
It is mainly caused by an inflammatory response and can be caused by food, intestinal microbial imbalance, and lifestyle habits.
@ 2024 . All rights reserved
@ 2024 . All rights reserved