Lambda Biologics liver organoids mirror the cellular diversity and metabolic functions of human liver tissue. They provide a powerful platform to study liver diseases such as hepatitis and fibrosis, while accurately modeling human drug metabolism and toxicity. With consistent differentiation and maturity, our organoids advance the development of safer, more effective therapies from discovery through translation.
Price | 5500€+ |
Organism | Human |
Product Type | iPS-derived organoid |
Tissue | Liver |
Disease | Fibrosis(IPF), Non-alcoholic fatty liver disease (NAFLD) |
Applications
Organoid Based Toxicity
With the global rise of K-beauty, the cosmetics industry continues to grow steadily. Since the ban on animal testing for cosmetics in Korea in 2017, various alternative testing methods have...
Traditional microscopy methods often require fluorescent labeling to analyze cellular structures, which can be time-consuming and invasive. In contrast, our HT-X1 system allows for high-resolution visualization of cellular morphology without...
Traditional protein analysis has primarily focused on quantifying expression levels within tissue samples. However, recent advances in spatial analysis techniques have shifted attention toward evaluating not only expression levels, but...
We conducted a study focused on identifying disease-related markers using patient-derived tissue samples. However, traditional methods limited our ability to analyze multiple candidate markers simultaneously, and the limited availability of...
Our liver organoids faithfully replicate the structure and function of human liver tissue by expressing key cellular markers. EpCAM is present in hepatocytes and cholangiocytes, confirming proper epithelial organization. AFP highlights immature hepatocytes, reflecting developmental processes, while Ki67 marks actively dividing hepatocytes and progenitor cells. ZO-1 demonstrates barrier integrity in hepatocytes and cholangiocytes, and HNF4A drives hepatocyte differentiation and maturation. In addition, E-cadherin (ECAD) ensures cell – cell adhesion between hepatocytes and cholangiocytes, supporting robust epithelial structures.
Together, these markers confirm that our liver organoids capture the cellular diversity, architecture, and functional complexity of the human liver – making them a powerful platform for disease modeling, metabolism studies, and drug testing.
Liver organoids can be observed in a mature form with hepatic layers, bile duct structures architecture similar to actual liver tissue.
They are also composed of various cells such as hepatocytes, cholangiocytes, Kupffer cells, stellate cells.
To induce a fatty liver model, we treated the liver organoids with free fatty acids.
It was confirmed that markers such as HNF4A, Albumin, and CYP3A4, which are indicative of healthy hepatocyte function, decreased in the damaged model.
This model can be used to evaluate effective substances related to fatty liver disease treatment.
After treating liver organoids with fatty acids, a fatty liver model was created, and lipid accumulation was assessed using LipidTox staining at Day 3 and Day 7. The results showed that at Day 3, lipid accumulation was observed at an early stage, while at Day 7, lipid accumulation was significantly more pronounced. This indicates that, over time, the accumulation of lipids in the liver organoids increases, suggesting that this model effectively simulates the development of fatty liver and can be used as a valid model for research.
Interested in bringing human-relevant liver models into your research?
Contact Lambda Biologics to discuss your project with our team.
Liver organoids are miniature, lab-grown liver models derived from human stem cells. They replicate key cell types and liver functions, making them valuable for studying liver development, disease modeling, drug testing, and toxicity screening. Unlike traditional cell cultures, they provide a more human-relevant system for accurate research results.
Yes. Liver organoids replicate human liver metabolism and cellular responses, allowing researchers to assess drug toxicity and efficacy in a human-relevant context, which improves the predictive power of preclinical studies.
We provide detailed technical data sheets covering differentiation methods, marker expression, and functional validation, so you can trust the reliability and reproducibility of your results.
Lambda Biologics provides custom liver organoid services, including generation, maturation, and functional assays. We support projects ranging from disease modeling to drug screening, offering high-quality, reproducible organoids that accelerate research and reduce reliance on animal models.
Simply contact Lambda Biologics team. Our scientists will review your project needs and provide the right options whether it’s technical guidance, a quote, or custom organoid development.
