A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion
Journal: Nature
Author: Falcomatà, Schaefer, Brown et al., USA
Spatial functional genomics identifies SERPINE1 and SERPINB2 as organizers of fibrin-rich niches that programme immunosuppressive macrophages, exclude T cells, and blunt anti-PD-1 in pancreatic cancer.
4D nucleome landscape reveals dissolution of bipartite active X chromosome in liver cancer development
Journal: Nature
Author: Xie, Tan, Wang et al., China
3DEEP pushes spatial transcriptomics hundreds of microns into intact tissue. Ordering hundreds of mouse hair follicles by molecular age turns one snapshot into 4D organogenesis.
Decoding spatiotemporal fibrotic and cellular immunosuppression of therapeutic T cells in live pancreatic ductal adenocarcinoma
Journal: Molecular System Biology
Author: Qian, G., Zhang, H., Stromnes, I.M. et al., USA
TME-CART couples 4D live-tumour imaging with deep learning, showing collagen fibres channel T cells while myeloid cells block them — and predicting what myeloid depletion fixes.
Chemical induction and reversal of photoreceptor dystrophy in retinal organoids
Journal: Stem Cell Reports
Author: Bradley A, Min H, Park S et al., USA
Blocking ATF6 with Ceapin-A7 stripped photoreceptor segments in human retinal organoids without killing cells. Removing the drug let segments regrow — a reversible, chemically controlled dystrophy model.
