Meet us at ACS FALL 18 - 20 August
ODISEI Organoid-based Discovery Platform Introduction
Home » Latest Research Trends » Organoid » Placenta-Derived Protein Breakthrough Boosts Liver Organoid Growth

Placenta-Derived Protein Breakthrough Boosts Liver Organoid Growth

Researchers at the University of Tokyo have discovered that placenta-derived IL1α under hypoxic conditions can dramatically increase the size and functionality of human stem cell-derived liver organoids by up to five times. The team identified that IL1α works through the SAA1-TLR2-CCL20-CCR6 signaling pathway to expand liver progenitor cells called hepatoblasts.
This breakthrough addresses a major challenge in organoid research – creating larger, more functional tissue models. By mimicking the natural developmental environment of fetal liver, including the timing of oxygen exposure, researchers have unlocked a method that could revolutionize both disease modeling and regenerative medicine.
The findings have significant implications for developing improved disease models, drug testing platforms, and potentially lab-grown organs for transplantation. This approach may also apply to other organ types, opening new possibilities for personalized medicine and therapeutic applications.

Subscribe
to the latest updates in the newsletter

Related Solutions

  • Disease Modeling
  • Oncology
  • Organoid
  • Cosmetics
  • OECD TG
  • Zebrafish
  • Bioinfomatics
  • Live&3D Imaging
  • Molecular biology
  • Spatial Biology

Next Articles

Connect with Us