Gentler Transplants: Antibody‑Only Conditioning Breakthrough in Fanconi Anemia
Journal: Nature Medicine
Author: Agarwal, R., Bertaina, A., Soco, C. et al. , USA
A novel conditioning protocol using anti‑CD117 and immunosuppression – without irradiation or busulfan – enables safe haploidentical stem cell transplantation in Fanconi anemia patients.
New Computational Method to Precisely Maps Single Cells to Spatial Locations in Tissues
Journal: Nature Communications
Author: Ke, J., Xu, J., Liu, J. et al., China
Researchers developed CMAP, a computational method that overcomes current limitations in spatial transcriptomics by integrating data, accurately mapping individual cells to their exact tissue locations.
Overcoming AAV-CRISPR Delivery Barriers in Brain Gene Editing
Journal: Molecular Therapy Nucleic Acids
Author: Kantor, Boris et al., USA
A comprehensive review highlights key obstacles in delivering CRISPR tools to the central nervous system using AAV vectors, and explores engineering strategies to enhance therapeutic potential.
Neutrophils Take the Lead in Driving Tumour Necrosis and Spread
Journal: Nature
Author: Adrover, J.M., Han, X., Sun, L. et al., USA
Neutrophils actively trigger tumour necrosis, vascular blockage, and enhance metastasis – shifting the paradigm from passive tumour cell death.
