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Latest Research Trends (02 May 2025)

EPO: The Unexpected Tumor Immunosuppression Master Switch

Journal: Science

Author: David Kung-Chun Chiu et al., USA

Researchers discovered that tumor-secreted erythropoietin (EPO) reprograms macrophages to create a tumor-friendly environment by blocking T-cell activity. Targeting the EPO pathway converts immunologically “cold” tumors to “hot,” making them responsive to immunotherapy.

Vascularized Placental Organoids Reveal Antiviral Defenses

Journal: Communications Biology

Author: Yaqing Wang et al., China

Scientists engineered human placental organoids with vascular endothelium that mimic early placental development. These enhanced organoids showed improved viability, activated immune pathways, and reduced susceptibility to Zika virus, highlighting the crucial role of the vascular niche.

High-Resolution Maps Uncover Pancreatic Cancer’s Adaptive Strategies

Journal: Nature

Author: Guangsheng Pei et al., USA

Spatially resolved transcriptomics of metastatic pancreatic cancer revealed how tumors adapt as they spread to different organs. The study identified unique cancer cell states, specific microenvironment interactions, and immune exclusion mechanisms that contribute to treatment resistance.

Two-Step Process Improves CRISPR Efficiency

Journal: Molecular Cell

Author: Honglue Shi et al., USA

Researchers identified the molecular basis for efficient CRISPR-Cas9 editing, revealing a trade-off between broad PAM recognition and editing effectiveness. The discovered two-step process—selective PAM binding followed by rapid DNA unwinding—offers a foundation for engineering more effective gene editors.

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