Label-free nanoscopy of cell metabolism by ultrasensitive reweighted visible stimulated Raman scattering
Journal: Nature Methods
Author: Haonan Lin et al., USA
Breakthrough URV-SRS (Ultrafast Resonant Vibrational Stimulated Raman Scattering) imaging achieves 86nm resolution in metabolite visualization, enabling label-free observation of cellular metabolic processes at unprecedented detail – transforming our ability to study cell metabolism.
A CD26+ tendon stem progenitor cell population contributes to tendon repair and heterotopic ossification
Journal: Nature Communications
Author: Siwen Chen et al., China
This research identifies CD26+ tendon stem/progenitor cells as key players in tendon healing and bone formation. These cells, residing in peritendon, demonstrate remarkable regenerative potential and offer new therapeutic targets through Tenascin-C-Hippo signaling pathways
An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development
Journal: Cell
Author: Marlies E. Oomen et al., Germany
Single-cell sequencing technology Smart-seq+5′ reveals unprecedented insights into mammalian embryonic genome activation across five species. The study uncovers extensive transposable element activity and its evolutionary role in early development, providing a comprehensive resource for understanding developmental transcription.
Advanced Delivery Systems for Gene Editing: A Comprehensive Review from the GenE-HumDi COST Action Working group
Journal: Molecular Therapy Nucleic Acids
Author: Alessia Cavazza et al., Italy
The comprehensive review examines genome editing delivery systems for clinical applications, highlighting both viral and non-viral approaches. The GenE-HumDi COST Action collaboration evaluates how these systems could overcome delivery barriers for both ex vivo and in vivo therapeutic applications.
