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skin-hair-follicle-organoid
Normal Organoid

Skin & Hair Organoid

3189€+
Normal Organoid

Skin & Hair Organoid

  • Skin & Hair organoids replicate the complex structure of hair follicles, allowing detailed studies of hair growth and regeneration.
  • They enable modeling of hair disorders such as alopecia, providing insights into disease mechanisms and potential therapeutic strategies.
  • Skin & hair organoids serve as effective models for testing the efficacy and safety of hair growth-promoting drugs and treatments.
Price
3189€+
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Organism
Human
Product Type
iPS-derived organoid
Tissue
Skin
Disease
Dermatitis, Atopic, Phototoxicity, Hair loss,  etc

Applications

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Professor Lee Chang-seok Eulji University
Customer insight

Advancing K-Beauty with Skin Organoids: A Next-Generation Platform for Non-Animal Testing and High-Precision Cosmetic Innovation

With the global rise of K-beauty, the cosmetics industry continues to grow steadily. Since the ban on animal testing for cosmetics in Korea in 2017, various alternative testing methods have...

Description

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Generation process of mature human skin organoid

We have developed hPSC-derived human skin organoids based on our differentiated technology to develop hair-bearing mature skin organoids.

Cellular and structural similarity

Our skin organoids can be observed in a mature form with the epidermal layer, dermal layer, and subcutaneous tissue that appear in actual skin structure.
It is also composed of various cells such as fibroblasts, melanocytes, hair follicle-related cells, and adipocytes.
Structural characteristics of  skin organoids

Advanced skin organoid manufacturing technology

previous method
Advanced method
Our skin organoids can be observed in a structurally mature form and are capable of uniformly forming a higher number of hair follicles.
Compared to traditional artificial skin models and 2D cell lines, our skin organoids exhibit superior performance in replicating the complexity and functionality of human skin.
Markers
  • KRT5
  • KRT17
  • EDAR
  • SOX2
Skin structure
  • Basal Layer [Epidermis]
  • Cornified envelope [Epidermis]
  • Hair Gem [Dermis]
  • Dermal papilla cell [Dermis]

Evaluation of drugs for hair formation effectiveness

Structural characteristics of  skin organoids
In order to discover drugs that help in the formation of hair, active substances were treated at the time when hair bulbs in skin organoids were formed, and drugs that increased hair follicle formation compared to the control group were selected.
When treated with an effective drug, an increase in the number of hair follicles was obtained, and additional research on mechanisms related to hair follicle formation was conducted.
Hair formation efficacy test in the skin organoids

Hair loss model production and effectiveness evaluation

To create a hair loss model, we treated skin organoids with hair with the male hormone DHT to create a hair loss model. It was confirmed that hair loss was suppressed by co-administration with Minoxidil, a known hair loss treatment, and was used to discover effective candidates.

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info@lambdabiologics.com

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