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Price | 2850€+ Login to see price |
Organism | Human |
Product Type | Organoid |
Tissue | Normal submandibular gland and parotid gland tissues |
Disease | – |
Applications
Toxicity
Organoid Based
Disease Modeling
Gland Disease Model
Histological analysis results (H&E, PAS) revealed an increase in cellular components and an observed increase in cells producing neutrophil mucin under organoid differentiation conditions.
Therefore, it was confirmed that the similarity with the tissue is more pronounced during differentiation induction.
In the organoids subjected to differentiation conditions, there was an increased expression of acinar cell markers (AQP5, AMY), and the expression of ductal cell markers (CK7, CK19) exhibited a polarized pattern, resembling the characteristics of actual ducts.
The ability to secrete saliva was verified by observing the response of calcium accumulation upon stimulation with the cholinergic agonist carbachol.
@ 2024 . All rights reserved
@ 2024 . All rights reserved
