Normal Organoid

Salivary Gland Organoid

Histologically similar to salivary gland tissue
Mimics the functional characteristics of salivary gland tissue.
Composed of various cell types, including acinar and ductal cells.


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Organism	Human
Product Type	Organoid
Tissue	Normal submandibular gland and parotid gland tissues
Disease	–

Applications

Toxicity

Organoid Based

Disease Modeling

Gland Disease Model

Description

Unlock the Potential of Salivary Gland Organoids for Ethical Research Applications

Histological analysis results (H&E, PAS) revealed an increase in cellular components and an observed increase in cells producing neutrophil mucin under organoid differentiation conditions.
Therefore, it was confirmed that the similarity with the tissue is more pronounced during differentiation induction.

Histology Data

Differential Expression of Acinar and Ductal Markers in Organoids

In the organoids subjected to differentiation conditions, there was an increased expression of acinar cell markers (AQP5, AMY), and the expression of ductal cell markers (CK7, CK19) exhibited a polarized pattern, resembling the characteristics of actual ducts.

IF Data

Carbachol Test

The ability to secrete saliva was verified by observing the response of calcium accumulation upon stimulation with the cholinergic agonist carbachol.