Price | 1000€+ Login to see price |
Organism | – |
Product Type | – |
Tissue | – |
Disease | – |
Applications
Holotomography
3D biology
With the global rise of K-beauty, the cosmetics industry continues to grow steadily. Since the ban on animal testing for cosmetics in Korea in 2017, various alternative testing methods have...
Traditional microscopy methods often require fluorescent labeling to analyze cellular structures, which can be time-consuming and invasive. In contrast, our HT-X1 system allows for high-resolution visualization of cellular morphology without...
Traditional protein analysis has primarily focused on quantifying expression levels within tissue samples. However, recent advances in spatial analysis techniques have shifted attention toward evaluating not only expression levels, but...
We conducted a study focused on identifying disease-related markers using patient-derived tissue samples. However, traditional methods limited our ability to analyze multiple candidate markers simultaneously, and the limited availability of...
HT offers two key applications in organoid research. First, it allows for the identification and long-term tracking of cell subtypes within small intestinal organoids without staining. Second, it visualizes and precisely quantifies the growth and development of hepatic organoids. The main advantage of HT is that organoid cultures remain intact after imaging, allowing for further experiments, making it valuable for drug development and personalized medicine strategies.
(A) Morphological features of small intestinal organoid.
(i) Lumen of organoid and the secreted contents.
(ii) Paneth cell, (iii) Enteroendocrine cell and (iv) Goblet cell. Scale bar: 20 μm.
(B) 3D visualization of organoid and masked cells, with TomoAnalysis.
The magenta line represents the XY slice presented in (i).
The blue area represents the masked region (above).
Each cells from Figure 2A are labeled as (ii) – (iv) (below).
MIP: Maximum Intensity Projection.
(A) Representative images of processed ROI for each organoid. Scale bar: 50 μm
(B) The development of the tracked organoids monitored by the volume and the dry mass.
(C) Relative changes of the volume and the dry mass with respect to the time point, t = 0. The dotted line represents the initial value at the timepoint, t = 0.
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