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Price | 1000€+ Login to see price |
Organism | – |
Product Type | – |
Tissue | – |
Disease | – |
Applications
Holotomography
3D biology
HT offers two key applications in organoid research. First, it allows for the identification and long-term tracking of cell subtypes within small intestinal organoids without staining. Second, it visualizes and precisely quantifies the growth and development of hepatic organoids. The main advantage of HT is that organoid cultures remain intact after imaging, allowing for further experiments, making it valuable for drug development and personalized medicine strategies.
(A) Morphological features of small intestinal organoid.
(i) Lumen of organoid and the secreted contents.
(ii) Paneth cell, (iii) Enteroendocrine cell and (iv) Goblet cell. Scale bar: 20 μm.
(B) 3D visualization of organoid and masked cells, with TomoAnalysis.
The magenta line represents the XY slice presented in (i).
The blue area represents the masked region (above).
Each cells from Figure 2A are labeled as (ii) – (iv) (below).
MIP: Maximum Intensity Projection.
(A) Representative images of processed ROI for each organoid. Scale bar: 50 μm
(B) The development of the tracked organoids monitored by the volume and the dry mass.
(C) Relative changes of the volume and the dry mass with respect to the time point, t = 0. The dotted line represents the initial value at the timepoint, t = 0.
