Price | 4850€+ Login to see price |
Organism | Human |
Product Type | Adult Tissue derived organoid |
Tissue | Lacrimal gland |
Disease | Gland Disease Model |
Applications
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With the global rise of K-beauty, the cosmetics industry continues to grow steadily. Since the ban on animal testing for cosmetics in Korea in 2017, various alternative testing methods have...
Traditional microscopy methods often require fluorescent labeling to analyze cellular structures, which can be time-consuming and invasive. In contrast, our HT-X1 system allows for high-resolution visualization of cellular morphology without...
Traditional protein analysis has primarily focused on quantifying expression levels within tissue samples. However, recent advances in spatial analysis techniques have shifted attention toward evaluating not only expression levels, but...
We conducted a study focused on identifying disease-related markers using patient-derived tissue samples. However, traditional methods limited our ability to analyze multiple candidate markers simultaneously, and the limited availability of...
In the lacrimal gland organoid, the structure of acinar cells and their secretion of acidic mucins were observed by H&E, Alcian blue.
Additionally, through PAS staining, secretions such as glycogen and glycoproteins were observed in the organoid.
Masson’s Trichrome staining demonstrated that keratin is a major ECM component in the organoid.
The expression patterns of VIM, AQP5, and LYZ within the organoid closely resemble those of the tissue’s acinar cells.
Furthermore, the expression patterns of E-CAD and α-SMA in the organoid are similar to those in the tissue, though at lower levels.
These markers are not expressed in ductal cells but are expressed in acinar cells, confirming that the formed organoid closely resembles acinar cells.
To assess the secretory function, lacrimal gland organoids were treated with pilocarpine.
The intracellular concentration of Ca ions increased, confirming the elevation of the lysosomal protein β-hexosaminidase, a component of tears.
Lambda Biologics GmbH
Deutscher Platz 5 c, 04103, Leipzig, Germany
info@lambdabiologics.com
