Lambda Biologics offers a human intestine organoid model that provides a human-derived in vitro platform for translational research, intestinal toxicity assessment, and disease-relevant studies. Generated from human stem cells, intestine organoids recapitulate key aspects of intestinal tissue organization and cellular diversity and can be integrated into CRO-based research workflows for pharma and biotech teams.
Price | 880€+ |
Organism | Human |
Product Type | iPS-derived organoid, Adult Tissue derived organoid |
Tissue | Colon, Small Intestine |
Disease | IBD, Inflammatory Bowel Disease, Leaky Gut Syndrome, Infectious enteric disease, Intestinal fibrosis model |
Applications
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I have been utilizing tumor organoid technology since 2020. Recently, I’ve come to appreciate how combining organoid technology with AI can revolutionize the drug discovery process by enhancing efficiency and...
iPSC-derived intestinal organoids are 3D models that replicate intestinal tissue using induced pluripotent stem cells (iPSCs), playing a key role in intestinal development and disease research. These organoids are generated by differentiating iPSCs into intestinal progenitor cells and cultivating them in a suitable extracellular matrix to form 3D structures. The organoids mature into structures with key intestinal layers and functions, which can be assessed through their absorption capacity, bacterial adhesion ability, and drug responses, mimicking real intestinal tissue.
Tissue-derived intestinal organoids are 3D models created using intestinal cells directly isolated from tissue, providing a valuable tool for studying intestinal development, function, and diseases. These organoids are typically generated by culturing intestinal epithelial cells derived from intestinal tissue. Under specialized culture conditions, the cells form 3D structures that closely mimic the natural architecture and function of the intestine. By providing extracellular matrix (ECM) components and growth factors, the cells spontaneously organize into the key layers and morphology of the intestine, maintaining a microenvironment similar to that of the native tissue. These organoids are widely used for modeling intestinal diseases, drug testing, and studying both physiological and pathological conditions of the intestine.
ATORM-C is an autologous tissue-derived, organoid-based regenerative medicine approach for intestinal tissue repair. Developed using the ATORM® platform, ATORM-C utilizes patient-derived intestinal organoids with high self-renewal and differentiation capacity to regenerate damaged intestinal mucosa. By directly transplanting organoids onto refractory lesions, this approach aims to induce tissue regeneration in conditions where inflammation is controlled but mucosal damage remains severe, such as inflammatory bowel disease, proctitis, and intractable intestinal ulcers.
The small intestine is a crucial organ responsible for nutrient absorption, consisting of four layers: the mucosa, submucosa, muscularis propria, and serosa. Inside the small intestine, villi maximize nutrient absorption, while crypts serve as regions where intestinal epithelial cells proliferate. Additionally, microvilli further expand the surface area for absorption. The major cell types include enterocytes responsible for nutrient uptake, goblet cells that secrete mucus, Paneth cells that produce antimicrobial peptides, enteroendocrine cells that release hormones, and intestinal stem cells that regenerate the intestinal epithelium. Intestinal organoids have a structure and cellular composition similar to human intestinal tissue and mimic the functions of the small intestine.
The small intestine is a crucial organ responsible for nutrient absorption, consisting of four layers: the mucosa, submucosa, muscularis propria, and serosa. Inside the small intestine, villi maximize nutrient absorption, while crypts serve as regions where intestinal epithelial cells proliferate. Additionally, microvilli further expand the surface area for absorption. The major cell types include enterocytes responsible for nutrient uptake, goblet cells that secrete mucus, Paneth cells that produce antimicrobial peptides, enteroendocrine cells that release hormones, and intestinal stem cells that regenerate the intestinal epithelium. Intestinal organoids have a structure and cellular composition similar to human intestinal tissue and mimic the functions of the small intestine.
The calcium imaging analysis showed that upon glucose stimulation, mature hIOs exhibited a rapid increase in ΔF/F₀ values, forming a peak followed by a gradual decline. In contrast, previous hIOs displayed weak calcium signaling with consistently low ΔF/F₀ values. This indicates that glucose sensing and signaling pathways in enteroendocrine cells are functionally active in mature hIOs.
Previous hIO
Mature hIO
The swelling assay revealed that upon forskolin treatment, mature hIOs displayed significant volumetric changes over 120 minutes, while previous hIOs showed minimal or no swelling. This demonstrates that ion transport and water movement via CFTR are active in mature hIOs, effectively replicating the physiological properties of intestinal epithelial cells.
Interested in bringing human-relevant intestine models into your research?
Contact Lambda Biologics to discuss your project with our team.
Intestine organoids are three-dimensional, human stem cell–derived in vitro models that recapitulate key structural and cellular features of intestinal tissue. They contain multiple intestinal epithelial cell types organized in a 3D architecture, enabling research on intestinal biology, disease mechanisms, and tissue responses in a controlled laboratory environment.
iPSC-derived organoids are generated by differentiating induced pluripotent stem cells into intestinal progenitors, enabling the study of development and genetic modeling. Tissue-derived organoids are created directly from patient or donor intestinal cells, making them highly suitable for disease modeling, drug testing, and personalized medicine.
Lambda Biologics intestine organoids are widely used to study intestinal development, host–microbe interactions, disease mechanisms, and to evaluate drug absorption, efficacy, and toxicity in a physiologically relevant 3D system.
Both iPSC-derived and tissue-derived organoids typically require an extracellular matrix (such as Matrigel or other hydrogels) and a defined medium enriched with growth factors (e.g., Wnt, R-spondin, EGF) to support self-organization and long-term viability.
Simply contact Lambda Biologics team. Our scientists will review your project needs and provide the right options whether it’s technical guidance, a quote, or custom organoid development.
