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intestinal-organoid
Normal Organoid

Intestinal Organoid

880€+
Normal Organoid

Intestinal Organoid

  • Intestinal organoids exhibit diverse cell types found in the human intestine, enabling detailed cellular studies.
    Exhibit diverse intestinal cell types, enable detailed cellular studies.
  • They can model various intestinal diseases, providing insights into disease mechanisms and potential treatments.
    Model intestinal diseases, offer insights into mechanisms, treatments.
  • Intestinal organoids serve as effective models for testing drug efficacy and toxicity relevant to gastrointestinal conditions.
    Effective models for testing drug efficacy, toxicity in gastrointestinal conditions.

Price
Organism
Human
Product Type
Organoid
Tissue
PSC, Intestinal tissue
Disease

Applications

Toxicity

Organoid Based

Microbiome

Probiotic Adhesion Assay (2D)

Host-Microbiome Study (3D)

Disease Modeling

GI Tract Disease Model

Description

Table of Contents

Generation process of mature human intestinal organoid (hIO)

We have developed highly functional organoids capable of long-term culture by applying our maturation technology to human intestinal organoids (hIO) derived from iPSCs.

Cellular and structural similarity

Our intestinal organoids arecomposed of cells that resemble those of a mature human intestine.

Immunofluorescent staining with a proliferation marker (Ki-67), an epithelial marker (ECAD) and mature intestinal markers (DEFA5, OLFM4, MUC13, and KRT20).

Functional similarity

Previous hIO

Mature hIO

Glucose-induced Ca2+ transients in real-time manner.
Mean values of peak fluorescence intensity by using Fluo-4-AM calcium indicator.

Representative images of the morphological changes after treatment with forskolin.

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