Endometrial Cancer Organoid

We performed immunofluorescence staining on our endometrial cancer organoids to confirm their similarity to patient tissue. The results demonstrated that both pan-cytokeratin (Pan-CK), an epithelial cell marker, and Vimentin (VIM), an endometrial cancer tumor marker, were expressed in a pattern similar to the patient tissue. Additionally, the expression of anti-estrogen receptor (ER-α) and anti-progesterone receptor (PR) in the organoids mirrored that in the patient tissue. These organoids, which faithfully replicate the cellular and molecular characteristics of the primary tumor, offer a powerful platform for developing and testing targeted treatments, studying tumor behavior, and exploring hormone receptor dynamics in endometrial cancer.