Holotomography

Cytotoxicity

Cell Viability and Death Studies
HT technology allows for 3D observation of cellular morphology without the need for labeling. This is useful for cytotoxicity studies, enabling quantitative analysis of structural changes and cell death processes.
Non-invasive 3D Imaging
HT provides 3D visualization of cells without labeling or staining, allowing for the measurement of refractive index, which can be used to quantify protein concentration, dry mass, and more.
Neuronal Cells and Parkinson’s Disease Research
HT can be used to analyze morphological and physiological changes in neuronal cells in a Parkinson’s disease model, allowing for quantitative classification of cell states.
Monitoring of Cell Death Induced by Photosensitizers
HT allows the monitoring of cell death processes induced by photosensitizers, observing changes such as cell shrinkage, membrane protrusion, and stress granule formation.
Versatile Experimental Design
HT can be used to design experiments for monitoring cell morphology and proliferation, observing early responses to chemical treatments, quantitatively assessing cell volume, dry mass, concentration, and sphericity, 3D observation of organelle positioning and morphological changes, and time-course observation of cytosolic contraction and relaxation movements.


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Applications

Holotomography

Cell biology

Description

Cytotoxicity

HT microscopes, using 3D holotomography, allow for label-free observation of individual cells over time, making them ideal for studying cell physiology.
This technology is useful for cell viability and toxicity studies, enabling researchers to monitor cell morphology and proliferation, observe early chemical responses, perform quantitative cell analysis, visualize 3D organelle changes, and track cell movement over time.

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