The OECD Test Guideline 437, commonly referred to as the Bovine Corneal Opacity and Permeability (BCOP) test, is an in vitro test method used to classify chemicals according to their potential to cause eye irritation or serious eye damage. This test is particularly significant because it offers an alternative to in vivo testing, which traditionally involved using live animals, and thus supports the principles of the 3Rs (Reduce, Refine, Replace) concerning animal testing.
Price | 2874€+ |
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Applications
OECD
Eye Irritation
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The primary purpose of the BCOP test is to evaluate the hazard of chemicals inducing eye damage through changes observed in both the opacity and the permeability of the bovine cornea, which is a part of the eye that plays a crucial role in focusing vision.
This index serves as a quantitative measure to evaluate the eye irritation potential of the test substance.
BCOP Opacity
BCOP Permeability
BCOP In Vitro Irritancy Score (Opacity+15* Permeability)
Human-like Response Accuracy: Our assay utilizes bovine corneas, closely replicating human corneal response, which provides more accurate results for eye irritation testing compared to other models.
Reduced Ethical Concerns: By employing bovine corneas from already slaughtered animals, our service minimizes ethical concerns, aligning with animal welfare standards while still delivering reliable data.
Efficient and Reliable: Benefit from our streamlined process that offers quick turnaround times and consistent, reproducible results, enabling faster decision-making in product safety evaluations.
Interested in bringing Bovine Cornea OECD TG 437 into your research?
Contact Lambda Biologics to discuss your project with our team.
The BCOP assay is an OECD-validated in vitro test that evaluates the potential of substances to cause serious eye damage by measuring corneal opacity and permeability in bovine corneas.
OECD TG 437 is used to identify GHS Eye Damage Category 1 substances and is widely accepted for regulatory safety assessment and hazard classification.
This assay is suitable for industrial chemicals, cosmetic ingredients and formulations, agrochemicals, and pharmaceutical compounds, including both liquids and solids.
Yes. The method uses bovine corneas sourced as by-products from the food industry and does not involve live animal testing, supporting 3Rs and alternative testing strategies.
Results are reported as an In Vitro Irritancy Score (IVIS) with clear interpretation based on OECD TG 437 decision criteria to support regulatory submissions.
