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Applications
OECD
Eye Irritation
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The OECD Test Guideline 437, commonly referred to as the Bovine Corneal Opacity and Permeability (BCOP) test, is an in vitro test method used to classify chemicals according to their potential to cause eye irritation or serious eye damage. This test is particularly significant because it offers an alternative to in vivo testing, which traditionally involved using live animals, and thus supports the principles of the 3Rs (Reduce, Refine, Replace) concerning animal testing.
To determine the eye irritation of a test substance, it is applied tothe cornea of a cow.
The opacity (cloudiness) and permeability of the cornea are then measured.
These measurements are used to calculate the OcularIrritation Index (IVIS), which is indicative of the test substance’s eye irritation potential.
Based on the opacity and permeability measurements obtained from the corneal exposure test, the ocular irritation index (IVIS) is calculated.
This index serves as a quantitative measure to evaluate the eye irritation potential of the test substance.
The primary purpose of the BCOP test is to evaluate the hazard of chemicals inducing eye damage through changes observed in both the opacity and the permeability of the bovine cornea, which is a part of the eye that plays a crucial role in focusing vision.
BCOP Opacity
BCOP Permeability
BCOP In Vitro Irritancy Score (Opacity+15* Permeability)
Lambda Biologics GmbH
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info@lambdabiologics.com
