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Organism | |
Product Type | Organoid |
Tissue | Normal submandibular gland and parotid gland tissues |
Disease |
Applications
Efficacy assay
Organoids are three-dimensional mini organs that mimic the functions of respective organs, reproducing their complex physiological structures and functions. Verify their efficacy with our advanced technology.
Toxicity test
Organoids are three-dimensional mini organs that mimic the functions of respective organs, reproducing their complex physiological structures and functions. Assess their toxicity with our advanced technology!
Head and neck cancer
Inflammatory Bowel Disease (IBD) refers to a chronic condition characterized by inflammation within the gastrointestinal tract, causing inflammation of the intestinal walls.
Infectious Disease
As a virus-infected model, the utilization of tonsil, adenoid, and lung organoids allows for the evaluation of antiviral drug efficacy and facilitates virus research.
Histological analysis results (H&E, PAS) revealed an increase in cellular components and an observed increase in cells producing neutrophil mucin under organoid differentiation conditions.
Therefore, it was confirmed that the similarity with the tissue is more pronounced during differentiation induction.
In the organoids subjected to differentiation conditions, there was an increased expression of acinar cell markers (AQP5, AMY), and the expression of ductal cell markers (CK7, CK19) exhibited a polarized pattern, resembling the characteristics of actual ducts.
The ability to secrete saliva was verified by observing the response of calcium accumulation upon stimulation with the cholinergic agonist carbachol.
@ 2024 . All rights reserved
@ 2024 . All rights reserved
